Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | ACMSD | Q8TDX5 | 3/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.55 |
| ▸ | HNF4A | P41235 | 2/20 | 0.55 |
| ▸ | DHFR | P00374 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.50 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.50 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.50 |
| ▸ | PPM1B | O75688 | 1/20 | 0.49 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.49 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23645608 | 0.87 | IKBKB (0.69) | IKBKBKMT2AKDM4EGFERRXFP1 | |
| SCHEMBL23645723 | 0.82 | ALDH1A1 (0.53) | IKBKBKMT2AKDM4EMEN1MAPT | |
| SCHEMBL12292220 | 0.81 | PTPN1 (0.66) | IKBKBKMT2AKDM4EACMSDMCL1 | |
| SCHEMBL30456877 | 0.81 | PPM1B (0.71) | IKBKBKMT2AKDM4EGFERRXFP1 | |
| SCHEMBL2575452 | 0.81 | PPM1B (0.71) | IKBKBKMT2AKDM4EGFERRXFP1 | |
| SCHEMBL2246915 | 0.81 | KMT2A (0.84) | IKBKBKMT2AKDM4EGFERRXFP1 | |
| SCHEMBL18176810 | 0.80 | AKR1C2 (0.67) | IKBKBKMT2AKDM4EGFERRXFP1 | |
| SCHEMBL27846422 | 0.80 | KMT2A (0.59) | IKBKBKMT2AKDM4EGFERRXFP1 | |
| SCHEMBL2426286 | 0.80 | KDM4E (0.59) | IKBKBKMT2AKDM4EGFERRXFP1 | |
| SCHEMBL23645564 | 0.78 | PTPN1 (0.48) | IKBKBKMT2AKDM4EGFERRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3915557-A1 | METHODS OF USE FOR TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | Aurigene Discovery Technologies Limited (IN) | 2021-12-01 | — | — | EP | disclosed |
| EP-3615027-B1 | METHODS OF USE FOR TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | AURIGENE DISCOVERY TECH LTD (IN) | 2021-07-14 | — | — | EP | disclosed |