Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 10/20 | 0.56 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | FABP4 | P15090 | 1/20 | 0.42 |
| ▸ | LDHA | P00338 | 1/20 | 0.42 |
| ▸ | KAT7 | O95251 | 1/20 | 0.41 |
| ▸ | KAT6B | Q8WYB5 | 1/20 | 0.41 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.41 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | HNF4A | P41235 | 1/20 | 0.40 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | MYC | P01106 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23644566 | 0.92 | DHODH (0.50) | DHODHAKR1C2AKR1C1FABP4LDHA | |
| SCHEMBL14784538 | 0.83 | PTPN1 (0.53) | DHODHAKR1C2AKR1C1LDHAMCL1 | |
| SCHEMBL14783661 | 0.78 | DCLRE1B (0.51) | DHODHAKR1C2AKR1C1MCL1 | |
| SCHEMBL24060357 | 0.77 | DHODH (0.47) | DHODHAKR1C2AKR1C1LDHADHFR | |
| SCHEMBL18311302 | 0.77 | KAT6A (0.58) | DHODHAKR1C2AKR1C1LDHAKAT7 | |
| SCHEMBL27759717 | 0.76 | BCL2L1 (0.48) | DHODHAKR1C2AKR1C1MCL1DHFR | |
| SCHEMBL6193196 | 0.75 | FABP4 (0.47) | DHODHAKR1C2AKR1C1FABP4LDHA | |
| SCHEMBL14783984 | 0.75 | MCL1 (0.42) | DHODHAKR1C2AKR1C1MCL1DHFR | |
| SCHEMBL27786187 | 0.74 | PTPN1 (0.58) | DHODHAKR1C2AKR1C1LDHAMCL1 | |
| SCHEMBL28201912 | 0.73 | TTR (0.53) | DHODHAKR1C2AKR1C1MCL1ACMSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3615027-B1 | METHODS OF USE FOR TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | AURIGENE DISCOVERY TECH LTD (IN) | 2021-07-14 | — | — | EP | disclosed |