Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA7 | P43166 | 2/20 | 0.36 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | KIF5B | P33176 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21611500 | 0.85 | MAPT (0.60) | MAPTLMNAALDH1A1PIN1SMN1; SMN2 | |
| SCHEMBL21611536 | 0.84 | MAPT (0.56) | MAPTLMNAALDH1A1PIN1SMN1; SMN2 | |
| SCHEMBL21611550 | 0.83 | MAPT (0.75) | MAPTLMNAALDH1A1PIN1SMN1; SMN2 | |
| SCHEMBL21611426 | 0.81 | MAPT (0.56) | MAPTLMNAALDH1A1PIN1SMN1; SMN2 | |
| SCHEMBL21611402 | 0.81 | MAPT (0.56) | MAPTLMNAALDH1A1PIN1SMN1; SMN2 | |
| SCHEMBL21611354 | 0.81 | MAPT (0.75) | MAPTLMNAALDH1A1PIN1SMN1; SMN2 | |
| SCHEMBL21611362 | 0.81 | MAPT (0.56) | MAPTLMNAALDH1A1PIN1SMN1; SMN2 | |
| SCHEMBL21858751 | 0.81 | MAPT (0.55) | MAPTLMNAALDH1A1PIN1SMN1; SMN2 | |
| SCHEMBL23646326 | 0.79 | EGFR (0.39) | MAPTLMNAALDH1A1SMN1; SMN2KDR | |
| SCHEMBL21611494 | 0.79 | MAPT (0.53) | MAPTLMNAALDH1A1PIN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210221785-A1 | AMINO-PYRIMIDONYL DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | VERNALIS (R&D) LTD (GB) | 2021-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210221785-A1 | AMINO-PYRIMIDONYL DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DHFR, QDPR, DPYD | MAPT 2373/4885LMNA 2178/4885ALDH1A1 1003/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.