Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | RAD52 | P43351 | 2/20 | 0.42 |
| ▸ | GFER | P55789 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | GCK | P35557 | 1/20 | 0.36 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | TRPC6 | Q9Y210 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL171290 | 0.84 | DRD4 (0.52) | SYKKDM5ADRD4DRD2MAP4K4 | |
| SCHEMBL13724434 | 0.82 | KDM5A (0.44) | SYKGAAMAPTGFERSMN1; SMN2 | |
| SCHEMBL13724359 | 0.81 | MAP3K12 (0.45) | KDM5ADRD4DRD2MAP4K4DRD3 | |
| SCHEMBL171089 | 0.81 | ALDH1A1 (0.43) | SYKSMN1; SMN2KDM4EDRD4DRD2 | |
| SCHEMBL13490551 | 0.80 | DRD2 (0.52) | DRD4DRD2HRH3DRD3 | |
| SCHEMBL3388699 | 0.79 | NOTUM (0.43) | KDM5A | |
| SCHEMBL30141664 | 0.79 | NOTUM (0.43) | KDM5A | |
| SCHEMBL15636018 | 0.76 | CHRNA7 (0.41) | MAPTGFERSMN1; SMN2KDM4EKDM5A | |
| SCHEMBL29739657 | 0.76 | KDM5A (0.40) | SMN1; SMN2KDM5AMAP4K4ALDH1A1 | |
| SCHEMBL1546893 | 0.76 | USP30 (0.48) | DRD4DRD2HRH3DRD3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021145520-A1 | 7-AMINO-3,4-DIHYDROPYRIMIDOPYRIMIDIN-2-ONE DERIVATIVE HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | 한국과학기술연구원 | 2021-07-22 | — | — | WO | disclosed |