SCHEMBL23653232

SCHEMBL23653232

CC(=O)c1cc2n(n1)CCCNC2

nearest known ligand 0.36

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CXCR4 P61073 1/20 0.36
PDCD1 Q15116 2/20 0.35
CD274 Q9NZQ7 2/20 0.35
SOD3 P08294 1/20 0.33
HDAC6 Q9UBN7 3/20 0.32
PNMT P11086 1/20 0.31
PDK1 Q15118 1/20 0.31
PDK2 Q15119 1/20 0.31
CHRNB2 P17787 1/20 0.30
CHRNA4 P43681 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23652744 0.91 PDCD1 (0.42) CXCR4PDCD1CD274SOD3HDAC6
SCHEMBL22831695 0.86 PDCD1 (0.36) CXCR4PDCD1CD274SOD3CHRNB2
SCHEMBL22887771 0.85 CHRNB2 (0.38) CXCR4PDCD1CD274SOD3PNMT
SCHEMBL24535290 0.84 PDCD1 (0.33) CXCR4PDCD1CD274SOD3HDAC6
SCHEMBL24535881 0.84 BAZ2B (0.41) CXCR4PDCD1CD274HDAC6
SCHEMBL30793821 0.84 PLAT (0.39) PDCD1CD274HDAC6
Hydrochloric Acid SCHEMBL25335409 0.84 CHRNB2 (0.37) CXCR4PDCD1CD274SOD3PNMT
Hydrochloric Acid SCHEMBL30917804 0.83 SOD3 (0.33) CXCR4PDCD1CD274SOD3HDAC6
SCHEMBL31207896 0.83 PDCD1 (0.33) CXCR4PDCD1CD274SOD3HDAC6
Hydrochloric Acid SCHEMBL25434869 0.83 SOD3 (0.33) CXCR4PDCD1CD274SOD3HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3851436-A1 NOVEL HETEROAROMATIC AMIDE DERIVATIVE AND MEDICINE CONTAINING SAME Kaken Pharmaceutical Co., Ltd. (JP) 2021-07-21 EP disclosed