SCHEMBL23653772

CN(c1ccc([C@H]2CC3(C)[C@@H](CC[C@@]3(O)C#CC(C)(C)C)[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]32)cc1)C(C)(C)C

nearest known ligand 0.88

Predicted protein targets (top 5)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1	P04150	19/20	0.88

▸	PGR	P06401	15/20	0.88

▸	AR	P10275	11/20	0.88

▸	CYP3A4	P08684	2/20	0.83

▸	CYP2C8	P10632	1/20	0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL20048092	1.00	NR3C1 (0.88)	NR3C1PGRARCYP3A4CYP2C8
SCHEMBL19042673	0.94	NR3C1 (1.00)	NR3C1PGRARCYP3A4CYP2C8
SCHEMBL21143406	0.91	NR3C1 (1.00)	NR3C1PGRARCYP3A4CYP2C8
SCHEMBL20048238	0.91	NR3C1 (1.00)	NR3C1PGRARCYP3A4CYP2C8
SCHEMBL20048418	0.91	NR3C1 (0.87)	NR3C1PGRARCYP3A4CYP2C8
SCHEMBL20048212	0.90	NR3C1 (1.00)	NR3C1PGRARCYP3A4CYP2C8
SCHEMBL30324808	0.90	NR3C1 (1.00)	NR3C1PGRARCYP3A4CYP2C8
SCHEMBL20048227	0.90	NR3C1 (1.00)	NR3C1PGRARCYP3A4CYP2C8
SCHEMBL19042724	0.89	NR3C1 (0.83)	NR3C1PGRARCYP3A4
SCHEMBL20048215	0.89	NR3C1 (0.82)	NR3C1PGRARCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-3851444-A1	INHIBITORS OF GLUCOCORTICOID RECEPTOR	Oric Pharmaceuticals, Inc. (US)	2021-07-21	—	—	EP	disclosed