Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PREP | P48147 | 1/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17053036 | 1.00 | HSD17B10 (0.45) | HSD17B10SMN1; SMN2NR1H2NR1H3NPC1 | |
| SCHEMBL1982884 | 1.00 | HSD17B10 (0.45) | HSD17B10SMN1; SMN2NR1H2NR1H3NPC1 | |
| SCHEMBL2095212 | 1.00 | HSD17B10 (0.45) | HSD17B10SMN1; SMN2NR1H2NR1H3NPC1 | |
| SCHEMBL3789080 | 1.00 | HSD17B10 (0.45) | HSD17B10SMN1; SMN2NR1H2NR1H3NPC1 | |
| SCHEMBL1983358 | 1.00 | HSD17B10 (0.45) | HSD17B10SMN1; SMN2NR1H2NR1H3NPC1 | |
| SCHEMBL6983332 | 1.00 | HSD17B10 (0.45) | HSD17B10SMN1; SMN2NR1H2NR1H3NPC1 | |
| SCHEMBL18428250 | 0.96 | NR1H2 (0.43) | HSD17B10SMN1; SMN2NR1H2NR1H3NPC1 | |
| SCHEMBL1135308 | 0.91 | GPR119 (0.39) | HSD17B10NR1H2NR1H3HPGD | |
| SCHEMBL3697263 | 0.91 | GPR119 (0.39) | HSD17B10NR1H2NR1H3HPGD | |
| SCHEMBL2411163 | 0.91 | GPR119 (0.39) | HSD17B10NR1H2NR1H3HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3601282-B1 | NOVEL PYRIDO[2,3-B]INDOLE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION | HOFFMANN LA ROCHE (CH) | 2021-07-21 | — | — | EP | disclosed |