Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2411163 | 1.00 | GPR119 (0.39) | GPR119HSD17B10NR1H2NR1H3CCR5 | |
| SCHEMBL1035621 | 1.00 | GPR119 (0.39) | GPR119HSD17B10NR1H2NR1H3CCR5 | |
| SCHEMBL1135308 | 1.00 | GPR119 (0.39) | GPR119HSD17B10NR1H2NR1H3CCR5 | |
| SCHEMBL12159521 | 1.00 | GPR119 (0.39) | GPR119HSD17B10NR1H2NR1H3CCR5 | |
| Hydrochloric Acid SCHEMBL1468786 | 0.98 | GPR119 (0.38) | GPR119HSD17B10NR1H2NR1H3CCR5 | |
| SCHEMBL23654034 | 0.91 | HSD17B10 (0.45) | HSD17B10NR1H2NR1H3HPGD | |
| SCHEMBL6983332 | 0.91 | HSD17B10 (0.45) | HSD17B10NR1H2NR1H3HPGD | |
| SCHEMBL1982884 | 0.91 | HSD17B10 (0.45) | HSD17B10NR1H2NR1H3HPGD | |
| SCHEMBL3789080 | 0.91 | HSD17B10 (0.45) | HSD17B10NR1H2NR1H3HPGD | |
| SCHEMBL2095212 | 0.91 | HSD17B10 (0.45) | HSD17B10NR1H2NR1H3HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188288-A1 | OCTAHYDRO-PYRROLO[3,4-B]PYRROLE N-OXIDES | Abbott Laboratories (US) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009114575-A1 | TRICYCLIC SPIRO PYRIMIDINE DERIVATIVES AS HISTAMINE H4 LIGAND | ABBOTT LABORATORIES (US) | 2009-09-17 | — | — | WO | disclosed |
| WO-2009036132-A1 | OCTAHYDRO-PYRROLO[3,4-B]PYRROLE N-OXIDES | ABBOTT LABORATORIES (US) | 2009-03-19 | — | — | WO | disclosed |
| EP-2001885-A2 | OCTAHYDRO-PYRROLO[3,4-B]PYRROLE DERIVATIVES | Abbott Laboratories (US) | 2008-12-17 | — | — | EP | disclosed |
| US-20080188452-A1 | Macrocyclic Benzofused Pyrimidine Derivatives | ABBVIE INC. | 2008-08-07 | — | — | US | disclosed |
| US-20080159958-A1 | DETERMINATION OF HISTAMINE-3 BIOACTIVITY | ABBOTT LABORATORIES (US) | 2008-07-03 | — | — | US | disclosed |
| WO-2008060767-A2 | MACROCYCLIC BENZOFUSED PYRIMIDINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2008-05-22 | — | — | WO | disclosed |
| WO-2007100990-A2 | OCTAHYDRO-PYRROLO[3,4-B] PYRROLE DERIVATIVES AND THEIR USE AS HISTAMINE-3 RECEPTOR LIGANDS | ABBOTT LABORATORIES (US) | 2007-09-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080188452-A1 | Macrocyclic Benzofused Pyrimidine Derivatives | DPYD, TYMS, UMPS | GPR119 1358/4885HSD17B10 1213/4885NR1H2 2355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.