Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | SLC22A2 | O15244 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | POLA1 | P09884 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16615496 | 0.89 | MAPT (0.44) | SLC22A2CYP3A4TMEM97ABCG2MAPT | |
| SCHEMBL16615506 | 0.80 | SLC22A2 (0.47) | SLC22A2CYP3A4TMEM97ABCG2 | |
| SCHEMBL16615677 | 0.80 | SLC22A2 (0.47) | SLC22A2CYP3A4TMEM97ABCG2 | |
| SCHEMBL19003159 | 0.80 | SLC22A2 (0.40) | SLC22A2CYP3A4TMEM97ABCG2MAPT | |
| SCHEMBL17997113 | 0.78 | SLC22A2 (0.57) | SLC22A2CYP3A4TMEM97ABCG2 | |
| SCHEMBL16599545 | 0.77 | PDE10A (0.43) | LMNASLC22A2MAPTKMT2ALIPG | |
| SCHEMBL3525978 | 0.77 | KMT2A (0.47) | LMNATP53SLC22A2CYP3A4TMEM97 | |
| SCHEMBL10283453 | 0.76 | POU2F2 (0.51) | SLC22A2CYP3A4TMEM97ABCG2MAPT | |
| SCHEMBL16615653 | 0.75 | LIPG (0.41) | MAPTLIPG | |
| SCHEMBL3524314 | 0.75 | LMNA (0.47) | LMNATP53SLC22A2CYP3A4TMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3389380-B1 | SPIROCYCLIC QUINOLIZINE DERIVATIVES USEFUL AS HIV INTEGRASE INHIBITORS | MERCK SHARP & DOHME (US) | 2021-07-21 | — | — | EP | disclosed |