Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 2/20 | 0.32 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.32 |
| ▸ | GABRR1 | P24046 | 5/20 | 0.31 |
| ▸ | GABRR2 | P28476 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13828461 | 0.75 | HSD11B1 (0.34) | GRM2GRM3GABRR1GABRR2 | |
| SCHEMBL284782 | 0.70 | GABRR1 (0.36) | GRM2GRM3GABRR1GABRR2 | |
| SCHEMBL27825601 | 0.69 | GABRR1 (0.34) | GRM2GRM3GABRR1GABRR2 | |
| SCHEMBL13077342 | 0.68 | POLB (0.46) | GRM2GRM3GABRR1GABRR2 | |
| Hydrochloric Acid SCHEMBL9659824 | 0.67 | GABRR1 (0.43) | GRM2GRM3GABRR1GABRR2 | |
| SCHEMBL19604954 | 0.65 | GABRR1 (0.34) | GRM2GRM3GABRR1GABRR2 | |
| SCHEMBL8926578 | 0.60 | CYP1A2 (0.37) | — | |
| SCHEMBL22133141 | 0.60 | ABAT (0.38) | GRM2GRM3GABRR1 | |
| SCHEMBL4920447 | 0.59 | — | — | |
| SCHEMBL1688785 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3851437-A2 | METHODS OF PREPARING 1H-PYRROLO[2,3-B]PYRIDINE DERIVATES | Vertex Pharmaceuticals Incorporated (US) | 2021-07-21 | — | — | EP | disclosed |