Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.30 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.30 |
| ▸ | SDHB | P21912 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16048520 | 0.87 | FFAR4 (0.49) | FFAR4CYP11B1CYP11B2PTGS2 | |
| SCHEMBL16048108 | 0.87 | FFAR4 (0.37) | FFAR4CYP11B1CYP11B2PTGS2PPARD | |
| SCHEMBL16048359 | 0.84 | FFAR4 (0.35) | FFAR4CYP11B1CYP11B2CA1CA2 | |
| SCHEMBL16048967 | 0.74 | PTGS1 (0.37) | FFAR4PTGS2 | |
| SCHEMBL23655493 | 0.73 | CYP11B1 (0.44) | FFAR4CYP11B1CYP11B2PPARDTDP1 | |
| SCHEMBL14125769 | 0.70 | CA2 (0.61) | PTGS2CA1CA2CA9 | |
| SCHEMBL18030113 | 0.67 | CA2 (0.68) | CA1CA2CA9KMT2A | |
| SCHEMBL2535956 | 0.66 | MEN1 (0.47) | TDP1POLBKMT2ANOTUM | |
| SCHEMBL5643020 | 0.65 | TAAR1 (0.44) | CA1CA2CA9TDP1POLB | |
| SCHEMBL11402662 | 0.64 | TRPM8 (0.47) | CA9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3409671-B1 | ISOTHIAZOLE DERIVATIVES AS GPR120 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES | JANSSEN PHARMACEUTICA NV (BE) | 2021-07-21 | — | — | EP | disclosed |