Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 4/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.37 |
| ▸ | HTR3B | O95264 | 1/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAT2A | P31153 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12444826 | 0.80 | TSHR (0.39) | TSHRHRH4KMT2AHTR3AHTR3E | |
| SCHEMBL2333603 | 0.79 | MEN1 (0.41) | TSHRHRH4KMT2AMEN1HTR3A | |
| SCHEMBL14716849 | 0.79 | TSHR (0.38) | TSHRHRH4KMT2AHTR3AHTR3E | |
| Hydrochloric Acid SCHEMBL2360446 | 0.78 | MEN1 (0.40) | TSHRHRH4KMT2AMEN1HTR3A | |
| SCHEMBL14733337 | 0.72 | ALOX15 (0.41) | TSHRHRH4ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL2361148 | 0.71 | HTR6 (0.39) | TSHRHRH4HTR3A | |
| SCHEMBL2329668 | 0.70 | ALOX15 (0.37) | HRH4HTR3A | |
| SCHEMBL2331812 | 0.70 | HRH4 (0.38) | HRH4HTR3A | |
| Hydrochloric Acid SCHEMBL14717021 | 0.70 | HTR6 (0.39) | TSHRHRH4HTR3A | |
| SCHEMBL2329791 | 0.70 | HRH4 (0.37) | HRH4KMT2AKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536711-A1 | 5-HT RECEPTOR MODULATORS | Cambridge Enterprise Limited (GB) | 2012-12-26 | — | — | EP | claimed |
| EP-2536711-A1 | 5-HT RECEPTOR MODULATORS | Cambridge Enterprise Limited (GB) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011098776-A1 | 5-HT RECEPTOR MODULATORS | CAMBRIDGE ENTERPRISE LIMITED (GB) | 2011-08-18 | — | — | WO | disclosed |