Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFRSF1A | P19438 | 5/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.34 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.34 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.34 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.34 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.34 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6532681 | 0.81 | HTR2C (0.49) | HTR2AHTR2CHTR2B | |
| SCHEMBL2365641 | 0.79 | HTR2A (0.43) | HTR2AHTR2CHTR2B | |
| SCHEMBL6631310 | 0.77 | FGFR4 (0.35) | MAPTKDM4EALDH1A1HTR2AHTR2C | |
| SCHEMBL12295748 | 0.75 | HTR2A (0.53) | TNFRSF1ATSHRMAPK1HSD17B10ERN1 | |
| SCHEMBL2365631 | 0.71 | DRD2 (0.40) | HSD17B10MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL2477900 | 0.71 | HTR2A (0.58) | HTR2AHTR2CHTR2B | |
| SCHEMBL2365900 | 0.70 | HTR2A (0.51) | HTR2AHTR2C | |
| SCHEMBL6653153 | 0.70 | HTR2C (0.38) | HTR2AHTR2C | |
| SCHEMBL6650634 | 0.69 | ALDH1A1 (0.39) | HSD17B10MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL1094195 | 0.69 | GAA (0.43) | MAPK1SLC6A9KCNK3MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2363394-A1 | 8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, its salts, solvates or hydrates and its use for the treatment of CNS disorders | Arena Pharmaceuticals, Inc. (US) | 2011-09-07 | — | — | EP | disclosed |