Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5028985 | 0.78 | CYP1A2 (0.54) | NPSR1NR4A2ALDH1A1LMNAHTT | |
| SCHEMBL5512428 | 0.71 | LMNA (0.41) | NPSR1NR4A2ALDH1A1LMNAGAA | |
| SCHEMBL8335107 | 0.68 | CYP3A4 (0.38) | NPSR1NR4A2ALDH1A1LMNAHTT | |
| SCHEMBL2365704 | 0.68 | CYP3A4 (0.50) | NPSR1NR4A2ALDH1A1LMNAHTT | |
| SCHEMBL6828158 | 0.68 | PTPN1 (0.40) | NPSR1NR4A2ALDH1A1LMNAHTT | |
| SCHEMBL6825466 | 0.68 | PTPN1 (0.40) | NPSR1NR4A2ALDH1A1LMNAHTT | |
| SCHEMBL6468905 | 0.67 | NPSR1 (0.52) | NPSR1NR4A2ALDH1A1LMNAHTT | |
| SCHEMBL30020366 | 0.67 | CYP1A2 (0.49) | NR4A2GAAMAPTPDE3BPDE3A | |
| SCHEMBL8380519 | 0.66 | CA1 (0.48) | NPSR1ALDH1A1LMNAGAATSHR | |
| SCHEMBL29049264 | 0.66 | CA12 (0.48) | NPSR1ALDH1A1GAATSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364973-B1 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC (US) | 2014-07-09 | — | — | EP | disclosed |
| EP-2364973-A1 | Heterocyclic inhibitors of MEK and Methods of use thereof | Array Biopharma, Inc. (US) | 2011-09-14 | — | — | EP | disclosed |
| EP-2134340-A1 | COMBINATION THERAPY COMPRISING AZD2171 AND AZD6244 OR MEK-INHIBITOR II | AstraZeneca AB (SE) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008125820-A1 | COMBINATION THERAPY COMPRISING AZD2171 AND AZD6244 OR MEK-INHIBITOR II | ASTRAZENECA AB (SE) | 2008-10-23 | — | — | WO | disclosed |
| WO-2008120004-A1 | COMBINATION OF A MEK- INHIBITOR AND A B-RAF INHIBITOR FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-10-09 | — | — | WO | disclosed |