Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10617236 | 0.78 | LMNA (0.49) | ERN1LMNAHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL28965446 | 0.78 | USP2 (0.41) | LMNAALDH1A1MAPK1NPC1TP53 | |
| SCHEMBL10913534 | 0.77 | LMNA (0.37) | ERN1LMNAHPGDALDH1A1 | |
| SCHEMBL232141 | 0.75 | ALDH1A1 (0.43) | ERN1LMNAHPGDALDH1A1MAPK1 | |
| SCHEMBL23660857 | 0.74 | LMNA (0.35) | ERN1LMNAHPGDALDH1A1 | |
| SCHEMBL4493633 | 0.69 | ALDH1A1 (0.44) | LMNADHODHALDH1A1MAPK1HTT | |
| SCHEMBL23660877 | 0.68 | SMN1; SMN2 (0.40) | HPGDDHODHALDH1A1MAPK1NOTUM | |
| SCHEMBL25184025 | 0.67 | ERN1 (0.44) | ERN1LMNAALDH1A1NPC1RAB9A | |
| SCHEMBL20803783 | 0.67 | POLB (0.40) | ERN1DHODHALDH1A1HTT | |
| SCHEMBL24861066 | 0.66 | ERN1 (0.57) | ERN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115611909-A | Tetrahydronaphthalene compound, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2023-01-17 | — | — | CN | disclosed |
| WO-2021143822-A1 | BICYCLIC IMIDE DERIVATIVE, PREPARATION METHOD THEREOF, AND APPLICATION THEREOF IN MEDICINE | 江苏恒瑞医药股份有限公司 | 2021-07-22 | — | — | WO | disclosed |