Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 9/20 | 0.65 |
| ▸ | THRA | P10827 | 6/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 7/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23663470 | 0.95 | THRB (0.60) | THRBTHRAL3MBTL1NPBWR1MCHR1 | |
| SCHEMBL22632721 | 0.88 | THRB (0.60) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL29632801 | 0.86 | THRB (0.64) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL22632750 | 0.85 | THRB (0.57) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL31258407 | 0.85 | THRB (0.57) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL29632797 | 0.84 | THRB (0.58) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL22632451 | 0.83 | THRA (0.64) | THRBTHRAL3MBTL1CYP2C9UGT1A1 | |
| SCHEMBL22632655 | 0.83 | THRB (0.59) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL22632658 | 0.83 | THRB (0.59) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL29527166 | 0.83 | THRB (0.56) | THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250320197-A1 | THYROID HORMONE RECEPTOR AGONISTS AND USE THEREOF | ECCOGENE INC (US) | 2025-10-16 | — | — | US | disclosed |
| US-20240190846-A1 | THYROID HORMONE RECEPTOR AGONISTS AND USE THEREOF | ECCOGENE INC. | 2024-06-13 | — | — | US | disclosed |
| US-11780825-B2 | Thyroid hormone receptor agonists and use thereof | ECCOGENE (SHANGHAI) CO., LTD. (CN) | 2023-10-10 | — | — | US | disclosed |
| US-11780825-B2 | Thyroid hormone receptor agonists and use thereof | ECCOGENE (SHANGHAI) CO., LTD. (CN) | 2023-10-10 | — | — | US | disclosed |
| US-11780825-B2 | Thyroid hormone receptor agonists and use thereof | ECCOGENE (SHANGHAI) CO., LTD. (CN) | 2023-10-10 | — | — | US | disclosed |
| US-20210230146-A1 | THYROID HORMONE RECEPTOR AGONISTS AND USE THEREOF | ECCOGENE INC. | 2021-07-29 | — | — | US | disclosed |
| US-20210230146-A1 | THYROID HORMONE RECEPTOR AGONISTS AND USE THEREOF | ECCOGENE INC. | 2021-07-29 | — | — | US | disclosed |
| WO-2021143706-A1 | SUBSTITUTED TRIAZINONES AS THYROID HORMONE RECEPTOR AGONISTS | ECCOGENE (SHANGHAI) CO., LTD. (CN) | 2021-07-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210230146-A1 | THYROID HORMONE RECEPTOR AGONISTS AND USE THEREOF | TSHR, THRA, THRB | THRB 3/4885THRA 2/4885L3MBTL1 4551/4885 |
| US-11780825-B2 | Thyroid hormone receptor agonists and use thereof | TSHR, THRA, THRB | THRB 3/4885THRA 2/4885L3MBTL1 4551/4885 |
| US-20250320197-A1 | THYROID HORMONE RECEPTOR AGONISTS AND USE THEREOF | TSHR, THRA, THRB | THRB 3/4885THRA 2/4885L3MBTL1 4551/4885 |
| US-20240190846-A1 | THYROID HORMONE RECEPTOR AGONISTS AND USE THEREOF | TSHR, THRA, THRB | THRB 3/4885THRA 2/4885L3MBTL1 4551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.