Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 7/20 | 0.58 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.57 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.47 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.47 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2367268 | 0.91 | TNIK (0.68) | TNIKCDK5CDK5R1MAPTTP53 | |
| SCHEMBL2423694 | 0.87 | ALDH1A1 (0.56) | TNIKCDK5CDK5R1MAPTLMNA | |
| SCHEMBL2397849 | 0.85 | TNIK (0.57) | TNIKMAPTTP53POLBLMNA | |
| SCHEMBL3398128 | 0.84 | TNIK (0.77) | TNIKMAPTTP53POLBLMNA | |
| SCHEMBL2367192 | 0.83 | TNIK (0.78) | TNIKCDK5CDK5R1MAPTTP53 | |
| SCHEMBL2366979 | 0.80 | TNIK (0.85) | TNIKMAPTTP53POLBLMNA | |
| SCHEMBL2367144 | 0.80 | TNIK (0.71) | TNIKMAPTTP53POLBLMNA | |
| SCHEMBL3398694 | 0.80 | TNIK (0.67) | TNIKMAPTTP53POLBLMNA | |
| SCHEMBL2367157 | 0.80 | TNIK (0.73) | TNIKMAPTTP53POLBLMNA | |
| SCHEMBL2367080 | 0.80 | TNIK (0.70) | TNIKMAPTTP53POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364149-A1 | TNIK INHIBITOR AND THE USE | National Cancer Center (JP) | 2011-09-14 | — | — | EP | disclosed |
| WO-2010064111-A1 | TNIK INHIBITOR AND THE USE | YAMADA TESSHI (JP) | 2010-06-10 | — | — | WO | disclosed |