Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 11/20 | 0.57 |
| ▸ | CSNK2A2 | P19784 | 4/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | SCD | O00767 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3394774 | 0.92 | TNIK (0.67) | TNIKTP53MAPTLMNAPOLB | |
| SCHEMBL3390562 | 0.92 | TNIK (0.67) | TNIKTP53MAPTLMNAPOLB | |
| SCHEMBL3396902 | 0.86 | TNIK (0.69) | TNIKTP53MAPTLMNAPOLB | |
| SCHEMBL13333398 | 0.86 | TNIK (0.69) | TNIKTP53MAPTLMNAPOLB | |
| SCHEMBL2367066 | 0.85 | TNIK (0.58) | TNIKCSNK2A2CSNK2A1TP53MAPT | |
| SCHEMBL3398128 | 0.83 | TNIK (0.77) | TNIKTP53MAPTLMNAPOLB | |
| SCHEMBL3434372 | 0.83 | TNIK (0.63) | TNIKTP53MAPTLMNAPOLB | |
| SCHEMBL3394542 | 0.81 | TNIK (0.74) | TNIKTP53MAPTLMNAPOLB | |
| SCHEMBL3393572 | 0.81 | TNIK (0.65) | TNIKTP53MAPTLMNAPOLB | |
| SCHEMBL3397322 | 0.81 | TNIK (0.62) | TNIKTP53MAPTLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364149-B1 | TNIK INHIBITOR AND THE USE | NAT CANCER CT (JP) | 2014-05-07 | — | — | EP | disclosed |
| EP-2364149-A1 | TNIK INHIBITOR AND THE USE | National Cancer Center (JP) | 2011-09-14 | — | — | EP | disclosed |
| WO-2010064111-A1 | TNIK INHIBITOR AND THE USE | YAMADA TESSHI (JP) | 2010-06-10 | — | — | WO | disclosed |