Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 7/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | ALPI | P09923 | 1/20 | 0.43 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6525933 | 0.86 | L3MBTL1 (0.51) | AHRPKMALPLALPIBCAT1 | |
| SCHEMBL29886879 | 0.86 | AHR (0.53) | AHRBCAT1L3MBTL1TTRSMN1; SMN2 | |
| SCHEMBL23693571 | 0.86 | AHR (0.53) | AHRBCAT1L3MBTL1TTRSMN1; SMN2 | |
| SCHEMBL9343280 | 0.84 | TTR (0.55) | AHRTTRSMN1; SMN2CA1CA2 | |
| SCHEMBL23673450 | 0.83 | PKM (0.46) | PKMALPLALPIL3MBTL1SMN1; SMN2 | |
| SCHEMBL6339918 | 0.83 | PKM (0.42) | PKMALPLALPIL3MBTL1SMN1; SMN2 | |
| SCHEMBL23673502 | 0.83 | PKM (0.42) | PKMALPLALPIL3MBTL1SMN1; SMN2 | |
| SCHEMBL2332575 | 0.81 | SMN1; SMN2 (0.59) | AHRBCAT1L3MBTL1SMN1; SMN2 | |
| SCHEMBL29886865 | 0.81 | SMN1; SMN2 (0.59) | AHRBCAT1L3MBTL1SMN1; SMN2 | |
| SCHEMBL8128583 | 0.80 | AHR (0.73) | AHRTTRMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114981251-B | Dibenzofuran derivative cathepsin K inhibitor and preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-114981251-A | Diphenyl furan derivative cathepsin K inhibitor and preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2022-08-30 | — | — | CN | disclosed |
| WO-2021147882-A1 | DIBENZOFURAN DERIVATIVE CATHEPSIN K INHIBITOR, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 深圳信立泰药业股份有限公司 | 2021-07-29 | — | — | WO | disclosed |
| WO-2021147882-A1 | DIBENZOFURAN DERIVATIVE CATHEPSIN K INHIBITOR, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 深圳信立泰药业股份有限公司 | 2021-07-29 | — | — | WO | disclosed |