Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 10/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 7/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29994736 | 1.00 | HPGD (0.52) | HPGDTSHRALDH1A1GAAMAPT | |
| SCHEMBL23675189 | 0.83 | VNN1 (0.46) | HPGDALDH1A1GAAMAPTGRM5 | |
| SCHEMBL29565236 | 0.83 | VNN1 (0.46) | HPGDALDH1A1GAAMAPTGRM5 | |
| SCHEMBL1427046 | 0.83 | MEN1 (0.59) | HPGDTSHRALDH1A1GRM5HSD11B1 | |
| SCHEMBL6824364 | 0.80 | GRM5 (0.51) | HPGDTSHRGRM5HSD11B1CNR1 | |
| SCHEMBL423467 | 0.80 | KMT2A (0.59) | HPGDTSHRGRM5HSD11B1CNR1 | |
| SCHEMBL990157 | 0.78 | GRM5 (0.64) | HPGDALDH1A1GAAGRM5 | |
| SCHEMBL423103 | 0.77 | GRM5 (0.48) | HPGDTSHRALDH1A1GRM5HSD11B1 | |
| SCHEMBL24185213 | 0.75 | HPGD (0.56) | HPGDTSHRALDH1A1GRM5 | |
| SCHEMBL20577446 | 0.75 | GRM5 (0.54) | HPGDALDH1A1GRM5HSD11B1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4228650-A1 | INHALED FORMULATIONS OF PGDH INHIBITORS AND METHODS OF USE THEREOF | Epirium Bio Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| EP-4093385-A1 | PGDH INHIBITORS AND METHODS OF MAKING AND USING | Myoforte Therapeutics Inc. (US) | 2022-11-30 | — | — | EP | disclosed |
| WO-2022082009-A1 | INHALED FORMULATIONS OF PGDH INHIBITORS AND METHODS OF USE THEREOF | EPIRIUM BIO INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| WO-2021151014-A1 | PGDH INHIBITORS AND METHODS OF MAKING AND USING | MYOFORTE THERAPEUTICS, INC. (US) | 2021-07-29 | — | — | WO | disclosed |