Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 14/20 | 0.53 |
| ▸ | CA2 | P00918 | 14/20 | 0.53 |
| ▸ | CA9 | Q16790 | 9/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23677279 | 0.88 | CA1 (0.57) | CA1CA2CA9CYP1A2ALDH1A1 | |
| SCHEMBL23677215 | 0.86 | CA1 (0.54) | CA1CA2CA9MEN1KMT2A | |
| SCHEMBL20131060 | 0.84 | MAPT (0.48) | CA1CA2CA9CYP1A2CA12 | |
| SCHEMBL23677261 | 0.81 | GRM4 (0.51) | CA1CA2CA9 | |
| SCHEMBL15613254 | 0.81 | MAPT (0.54) | CA1CA2CA9CYP1A2CA12 | |
| SCHEMBL20131057 | 0.79 | CYP1A2 (0.50) | CA1CA2CA9CYP1A2CA12 | |
| SCHEMBL20131064 | 0.78 | PTGES2 (0.48) | CA1CA2CA9CYP1A2CA12 | |
| SCHEMBL15612974 | 0.78 | POLB (0.42) | CA1CA2CA9MAPTMEN1 | |
| SCHEMBL21623209 | 0.78 | CYP1A2 (0.54) | CA1CA2CA9CYP1A2CA12 | |
| SCHEMBL21623572 | 0.78 | CYP1A2 (0.74) | CA1CA2CA9CYP1A2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2890375-B1 | SULFAMOYL-ARYLAMIDES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-07-28 | — | — | EP | disclosed |