Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | TGM2 | P21980 | 1/20 | 0.63 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.55 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.52 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.52 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.50 |
| ▸ | CAPN2 | P17655 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23680015 | 0.95 | TGM2 (0.67) | HTTTGM2HDAC3HDAC4HDAC1 | |
| SCHEMBL16322823 | 0.95 | TGM2 (0.67) | HTTTGM2HDAC3HDAC4HDAC1 | |
| SCHEMBL195242 | 0.85 | TGM2 (0.61) | HTTTGM2SMN1; SMN2LMNAKEAP1 | |
| SCHEMBL17752539 | 0.84 | TGM2 (0.66) | HTTTGM2SMN1; SMN2LMNAKEAP1 | |
| SCHEMBL9825023 | 0.84 | ALDH1A1 (0.55) | HTTTGM2SMN1; SMN2LMNATPSAB1 | |
| SCHEMBL7820797 | 0.84 | HTT (0.89) | HTTTGM2HDAC3HDAC4HDAC1 | |
| SCHEMBL10559158 | 0.84 | HTT (0.74) | HTTTGM2HDAC3HDAC4HDAC1 | |
| SCHEMBL16323167 | 0.83 | TGM2 (0.72) | HTTTGM2SMN1; SMN2LMNAKEAP1 | |
| SCHEMBL15548368 | 0.83 | HDAC3 (0.78) | HTTTGM2HDAC3HDAC4HDAC1 | |
| SCHEMBL11011091 | 0.83 | HTT (0.76) | HTTTGM2HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3854789-A1 | MACROCYCLIC COMPOUNDS USEFUL AS CHITINASE INHIBITORS | CYGNET BIOSCIENCES B.V. (CW) | 2021-07-28 | — | — | EP | disclosed |