SCHEMBL2368022

SCHEMBL2368022

C=C(CC(=O)OC(C(F)(F)F)(C(F)(F)F)C(F)(F)F)C(=O)OC(C(F)(F)F)(C(F)(F)F)C(F)(F)F

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2367894 0.84 ALOX15 (0.36)
SCHEMBL8639456 0.77
SCHEMBL7762769 0.76
SCHEMBL4925399 0.76
SCHEMBL942320 0.74 THRB (0.31)
SCHEMBL2368409 0.74
SCHEMBL8640945 0.74
SCHEMBL5144605 0.73
SCHEMBL10799219 0.73 THRB (0.31)
SCHEMBL8641574 0.72

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8288496-B2 Contact lens and its manufacturing method NIPPON CONTACT LENS INC. (JP) 2012-10-16 US disclosed
US-8246168-B2 Methacrylate-based bulky side-chain siloxane cross linkers for optical medical devices BAUSCH & LOMB INCORPORATED (US) 2012-08-21 US disclosed
US-20110237701-A1 CONTACT LENS AND ITS MANUFACTURING METHOD NIPPON CONTACT LENS INC. (JP) 2011-09-29 US disclosed
EP-2369370-A2 Contact lens and its manufacturing method Nippon Contact Lens Inc. (JP) 2011-09-28 EP disclosed
US-20100118261-A1 METHACRYLATE-BASED BULKY SIDE-CHAIN SILOXANE CROSS LINKERS FOR OPTICAL MEDICAL DEVICES VRX HOLDCO LLC 2010-05-13 US disclosed
EP-1889098-A1 RIGID GAS PERMEABLE LENS MATERIAL BAUSCH & LOMB INCORPORATED (US) 2008-02-20 EP disclosed
WO-2006132844-A1 RIGID GAS PERMEABLE LENS MATERIAL BAUSCH & LOMB INCORPORATED (US) 2006-12-14 WO disclosed
EP-1355963-B1 POLYMERIC BIOMATERIALS CONTAINING SILSESQUIOXANE MONOMERS BAUSCH & LOMB (US) 2006-04-12 EP disclosed
EP-1355963-A2 POLYMERIC BIOMATERIALS CONTAINING SILSESQUIXANE MONOMERS BAUSCH & LOMB INCORPORATED (US) 2003-10-29 EP disclosed
US-6586548-B2 Useful as ophthalmic/contact lenses; impact strength; biocompatability BAUSCH & LOMB INCORPORATED 2003-07-01 US disclosed
US-20020128414-A1 Polymeric biomaterials containing silsesquixane monomers BAUSCH HEALTH MAGYARORSZAG KFT (A/K/A BAUSCH HEALTH HUNGARY LLC) (HU) 2002-09-12 US disclosed
WO-2002050144-A2 POLYMERIC BIOMATERIALS CONTAINING SILSESQUIXANE MONOMERS BAUSCH & LOMB INCORPORATED (US) 2002-06-27 WO disclosed
EP-0692100-B1 IMPROVED ITACONATE COPOLYMERIC COMPOSITIONS FOR CONTACT LENSES POLYMER TECHNOLOGY CORP (US) 1999-07-21 EP disclosed
EP-0692100-A1 IMPROVED ITACONATE COPOLYMERIC COMPOSITIONS FOR CONTACT LENSES POLYMER TECHNOLOGY CORPORATION (US) 1996-01-17 EP disclosed
WO-1994023314-A1 IMPROVED ITACONATE COPOLYMERIC COMPOSITIONS FOR CONTACT LENSES POLYMER TECHNOLOGY CORPORATION (US) 1994-10-13 WO disclosed
US-5346976-A Itaconate copolymeric compositions for contact lenses POLYMER TECHNOLOGY CORPORATION (US) 1994-09-13 US disclosed