Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | SCN8A | Q9UQD0 | 8/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SCN4A | P35499 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25822291 | 0.84 | ALDH1A1 (0.44) | ALDH1A1KDM4ESCN8AMAPTL3MBTL1 | |
| SCHEMBL12440953 | 0.81 | KDM4E (0.42) | ALDH1A1KDM4ESCN8AMAPTL3MBTL1 | |
| SCHEMBL31093921 | 0.78 | ALDH1A1 (0.40) | ALDH1A1KDM4ESCN8AMAPTL3MBTL1 | |
| SCHEMBL15869722 | 0.77 | KCNA3 (0.45) | ALDH1A1SCN8AMAPTL3MBTL1LMNA | |
| SCHEMBL16954269 | 0.77 | ALDH1A1 (0.44) | ALDH1A1KDM4ESCN8AMAPTL3MBTL1 | |
| SCHEMBL30195878 | 0.77 | ALDH1A1 (0.44) | ALDH1A1KDM4ESCN8AMAPTL3MBTL1 | |
| SCHEMBL9957027 | 0.77 | ALDH1A1 (0.46) | ALDH1A1KDM4EMAPTL3MBTL1LMNA | |
| SCHEMBL515980 | 0.77 | ALDH1A1 (0.61) | ALDH1A1KDM4ESCN8AMAPTLMNA | |
| SCHEMBL28602270 | 0.75 | ALDH1A1 (0.57) | ALDH1A1KDM4ESCN8AMAPTL3MBTL1 | |
| SCHEMBL24553670 | 0.75 | DYRK1A (0.35) | ALDH1A1KDM4ESCN8AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3423440-B9 | 5-METHYL-6-PHENYL-4,5-DIHYDRO-2H-PYRIDAZIN-3-ONE DERIVATIVE FOR THE TREATMENT OF BRAIN TUMORS | OTSUKA PHARMA CO LTD (JP) | 2021-07-28 | — | — | EP | disclosed |