Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LPL | P06858 | 5/20 | 0.40 |
| ▸ | LIPG | Q9Y5X9 | 5/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26336096 | 0.87 | LPL (0.39) | ALDH1A1LPLLIPGCYP1A2CYP2C19 | |
| SCHEMBL18174184 | 0.86 | LPL (0.40) | ALDH1A1LPLLIPGL3MBTL1MAPT | |
| SCHEMBL13043663 | 0.86 | LPL (0.40) | LPLLIPGL3MBTL1MAPTTDP1 | |
| SCHEMBL30594507 | 0.85 | MAPT (0.38) | ALDH1A1LPLLIPGL3MBTL1MAPT | |
| SCHEMBL26111453 | 0.85 | MAPT (0.38) | ALDH1A1LPLLIPGL3MBTL1MAPT | |
| SCHEMBL26111348 | 0.84 | ALDH1A1 (0.39) | ALDH1A1LPLLIPGL3MBTL1MAPT | |
| SCHEMBL15551341 | 0.84 | LPL (0.38) | ALDH1A1LPLLIPGL3MBTL1MAPT | |
| SCHEMBL29605546 | 0.83 | LPL (0.38) | LPLLIPG | |
| SCHEMBL4259193 | 0.83 | LPL (0.38) | LPLLIPG | |
| SCHEMBL29534512 | 0.82 | LPL (0.37) | ALDH1A1LPLLIPGL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022082009-A1 | INHALED FORMULATIONS OF PGDH INHIBITORS AND METHODS OF USE THEREOF | EPIRIUM BIO INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| WO-2021151014-A1 | PGDH INHIBITORS AND METHODS OF MAKING AND USING | MYOFORTE THERAPEUTICS, INC. (US) | 2021-07-29 | — | — | WO | disclosed |