Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21653689 | 0.88 | — | — | |
| SCHEMBL13621435 | 0.76 | THRB (0.33) | THRBMEN1KMT2A | |
| SCHEMBL13638116 | 0.72 | MEN1 (0.35) | MEN1KMT2A | |
| SCHEMBL23683087 | 0.72 | — | — | |
| SCHEMBL23683147 | 0.72 | THRB (0.35) | THRBMEN1KMT2A | |
| SCHEMBL21524358 | 0.72 | MAPK1 (0.32) | — | |
| SCHEMBL21020829 | 0.72 | — | — | |
| SCHEMBL2087274 | 0.70 | MAPK1 (0.50) | — | |
| SCHEMBL4924453 | 0.70 | MAPK1 (0.50) | — | |
| SCHEMBL15664157 | 0.70 | MEN1 (0.38) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021149817-A1 | Enhancement of anti-tumor activity of SHP2 inhibitor pyrimidinone in combination with novel cancer medicines in cancers | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2021-07-29 | — | — | WO | disclosed |