⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2368638 | 1.00 | — | — | |
| SCHEMBL2368639 | 0.79 | — | — | |
| SCHEMBL19696190 | 0.79 | — | — | |
| SCHEMBL22607437 | 0.76 | — | — | |
| SCHEMBL9775701 | 0.71 | — | — | |
| SCHEMBL27908271 | 0.71 | — | — | |
| SCHEMBL14878 | 0.71 | — | — | |
| SCHEMBL11130642 | 0.67 | CCR2 (0.33) | — | |
| SCHEMBL30192631 | 0.63 | L3MBTL1 (0.32) | — | |
| SCHEMBL30170167 | 0.63 | L3MBTL1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9249155-B2 | Thieno [2, 3-D] pyrimidine derivatives and their use to treat arrhythmia | XENTION LIMITED (GB) | 2016-02-02 | — | — | US | disclosed |
| EP-2694518-B1 | THIENO[2,3-D]PYRIMIDINE DERIVATIVES AND THEIR USE TO TREAT ARRHYTHMIA | XENTION LTD (GB) | 2015-10-07 | — | — | EP | disclosed |
| US-20140206703-A1 | THIENO [2, 3-D] PYRIMIDINE DERIVATIVES AND THEIR USE TO TREAT ARRHYTHMIA | XENTION LIMITED (GB) | 2014-07-24 | — | — | US | disclosed |
| EP-2694518-A1 | THIENO [2, 3 -D]PYRIMIDINE DERIVATIVES AND THEIR USE TO TREAT ARRHYTHMIA | Xention Limited (GB) | 2014-02-12 | — | — | EP | disclosed |
| WO-2012131379-A1 | THIENO [2, 3 -D] PYRIMIDINE DERIVATIVES AND THEIR USE TO TREAT ARRHYTHMIA | XENTION LIMITED (GB) | 2012-10-04 | — | — | WO | disclosed |
| US-8022076-B2 | Thieno[2,3-d]pyrimidine derivatives as potassium channel modulators; antiarrhythmia agents | XENTION LIMITED (GB) | 2011-09-20 | — | — | US | disclosed |
| EP-1641803-B3 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2010-12-08 | — | — | EP | disclosed |
| EP-1641803-B1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2009-03-18 | — | — | EP | disclosed |
| US-20050026935-A1 | Compounds | XENTION DISCOVERY LTD. | 2005-02-03 | — | — | US | disclosed |