Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB2 | Q9UBS0 | 2/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3249226 | 0.89 | RPS6KB2 (0.57) | RPS6KB2KCNH2ALDH1A1MAPTKDM4E | |
| SCHEMBL153244 | 0.81 | DYRK1A (0.53) | RPS6KB2KCNH2MAPTKDM4ESLC6A9 | |
| SCHEMBL8190730 | 0.80 | KCNH2 (0.44) | RPS6KB2KCNH2MAPTALOX5SLC6A9 | |
| SCHEMBL8190732 | 0.79 | KCNH2 (0.42) | RPS6KB2KCNH2ALDH1A1ALOX5SLC6A9 | |
| SCHEMBL9784218 | 0.79 | CTNNB1 (0.50) | RPS6KB2KCNH2MAPTSLC6A9SMN1; SMN2 | |
| SCHEMBL27690419 | 0.77 | MAOB (0.51) | RPS6KB2KCNH2ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL5171855 | 0.76 | NPC1 (0.66) | ALDH1A1MAPTKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL15677665 | 0.76 | ALOX5 (0.72) | ALDH1A1MAPTGAAKDM4EALOX5 | |
| SCHEMBL25094100 | 0.71 | HDAC6 (0.52) | ALDH1A1MAPTALOX5SMN1; SMN2NPC1 | |
| SCHEMBL338810 | 0.71 | LTA4H (0.70) | KCNH2ALDH1A1MAPTKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022076-B2 | Thieno[2,3-d]pyrimidine derivatives as potassium channel modulators; antiarrhythmia agents | XENTION LIMITED (GB) | 2011-09-20 | — | — | US | disclosed |
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |