Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.62 |
| ▸ | CPB2 | Q96IY4 | 5/20 | 0.47 |
| ▸ | DPP7 | Q9UHL4 | 6/20 | 0.43 |
| ▸ | DPP4 | P27487 | 4/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.42 |
| ▸ | FAP | Q12884 | 1/20 | 0.42 |
| ▸ | ARG2 | P78540 | 4/20 | 0.41 |
| ▸ | ARG1 | P05089 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL2100363 | 1.00 | GSR (0.62) | GSRCPB2DPP7DPP4DPP8 | |
| Lysine SCHEMBL23728835 | 0.85 | GSR (0.87) | GSRCPB2ARG2ARG1 | |
| Lysine SCHEMBL18986644 | 0.85 | GSR (0.87) | GSRCPB2ARG2ARG1 | |
| Norleucine SCHEMBL29557418 | 0.84 | METAP1 (0.51) | DPP7DPP4DPP8DPP9FAP | |
| Norleucine SCHEMBL14935842 | 0.84 | METAP1 (0.51) | DPP7DPP4DPP8DPP9FAP | |
| Lysine SCHEMBL237658 | 0.84 | GSR (0.54) | GSRCPB2DPP7DPP4DPP8 | |
| Lysine SCHEMBL237659 | 0.84 | GSR (0.54) | GSRCPB2DPP7DPP4DPP8 | |
| D-Glutamate SCHEMBL27975473 | 0.81 | GRM8 (0.60) | GSRDPP7DPP4DPP8DPP9 | |
| Glutamic Acid SCHEMBL27975498 | 0.81 | GRM8 (0.60) | GSRDPP7DPP4DPP8DPP9 | |
| SCHEMBL22197609 | 0.79 | CPB2 (0.54) | GSRCPB2DPP7DPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3414005-A1 | CRYOGEL FOR THE REMOVAL OF HEPARINS AND HEPARINOIDS FROM AQUEOUS SOLUTIONS, PHYSIOLOGICAL SOLUTIONS AND BIOLOGICAL FLUIDS, PREPARATION PROCESS AND USES THEREOF | Consiglio Nazionale Delle Ricerche (IT) | 2018-12-19 | — | — | EP | disclosed |
| WO-2017137919-A1 | CRYOGEL FOR THE REMOVAL OF HEPARINS AND HEPARINOIDS FROM AQUEOUS SOLUTIONS, PHYSIOLOGICAL SOLUTIONS AND BIOLOGICAL FLUIDS, PREPARATION PROCESS AND USES THEREOF | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 2017-08-17 | — | — | WO | disclosed |
| WO-2011109767-A2 | GELATINASE INHIBITORS AND PRODRUGS | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2011-09-09 | — | — | WO | disclosed |
| EP-1896135-A2 | PROCESSES FOR PRODUCTION OF 4-(BIPHENYLYL)AZETIDIN-2-ONE PHOSPHONIC ACIDS | Microbia, Inc. (US) | 2008-03-12 | — | — | EP | disclosed |
| WO-2006127893-A2 | PROCESSES FOR PRODUCTION OF 4-(BIPHENYLYL)AZETIDIN-2-ONE PHOSPHONIC ACIDS | MICROBIA, INC. (US) | 2006-11-30 | — | — | WO | disclosed |
| WO-2004008151-A2 | NEW COMBINATORIAL PEPTIDE LIBRARIES CONTAINING MARKERS AND METHODS FOR THEIR PREPARATION AND UTILIZATION | COMGENEX RT. (HU) | 2004-01-22 | — | — | WO | disclosed |