Norleucine

Norleucine

SCHEMBL29557418

C1CCC(NC2CCCCC2)CC1.CCCC[C@H](N)C(=O)O

nearest known ligand 0.51

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ METAP1 P53582 1/20 0.51
▸ SLC1A2 P43004 2/20 0.46
▸ SLC1A1 P43005 2/20 0.46
▸ SLC1A3 P43003 1/20 0.46
▸ SMN1; SMN2 Q16637 1/20 0.44
▸ DDAH1 O94760 2/20 0.43
▸ SIGMAR1 Q99720 1/20 0.43
▸ EPHX1 P07099 5/20 0.42
▸ DPP7 Q9UHL4 3/20 0.42
▸ DPP4 P27487 2/20 0.42
▸ DPP8 Q6V1X1 2/20 0.42
▸ DPP9 Q86TI2 2/20 0.42
▸ NOD1 Q9Y239 1/20 0.42
▸ FAP Q12884 1/20 0.42
▸ GRIK1 P39086 1/20 0.41
▸ GRIK2 Q13002 1/20 0.41
▸ SLC15A1 P46059 1/20 0.41
▸ NOS1 P29475 1/20 0.41
▸ EPHX2 P34913 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Norleucine SCHEMBL14935842 1.00 METAP1 (0.51) METAP1SLC1A2SLC1A1SLC1A3SMN1; SMN2
Biphenyl SCHEMBL14247678 0.85 SLC1A2 (0.50) METAP1SLC1A2SLC1A1SLC1A3DDAH1
Lysine SCHEMBL2369399 0.84 GSR (0.62) DPP7DPP4DPP8DPP9FAP
Lysine SCHEMBL2100363 0.84 GSR (0.62) DPP7DPP4DPP8DPP9FAP
Norleucine SCHEMBL28461745 0.84 SLC1A2 (0.49) METAP1SLC1A2SLC1A1SLC1A3DDAH1
2-Ethylhexanoic Acid SCHEMBL11502267 0.81 CA2 (0.62) SLC1A2SLC1A1SLC1A3SMN1; SMN2SIGMAR1
D-Glutamate SCHEMBL27975473 0.81 GRM8 (0.60) SLC1A2SLC1A1SLC1A3SMN1; SMN2DPP7
Glutamic Acid SCHEMBL27975498 0.81 GRM8 (0.60) SLC1A2SLC1A1SLC1A3SMN1; SMN2DPP7
SCHEMBL9825772 0.79 SIGMAR1 (0.57) METAP1SIGMAR1EPHX1DPP7DPP4
SCHEMBL27980206 0.79 EPHX1 (0.49) SMN1; SMN2EPHX1EPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250367300-A1 Nanomaterial and Methods of Use Thereof UNIVERSITY OF CONNECTICUT (US) 2025-12-04 — — US disclosed
US-20250302971-A1 Therapeutic Nanomaterials UNIV CONNECTICUT (US) 2025-10-02 — — US disclosed
US-20250302762-A1 NANOMATERIAL DELIVERY VEHICLE AND METHOD OF USE THEREOF UNIVERSITY OF CONNECTICUT (US) 2025-10-02 — — US disclosed
US-20250229081-A1 NANOMATERIAL COATED ELECTRODE AND METHODS OF USE THEREOF UNIVERSITY OF CONNECTICUT 2025-07-17 — — US disclosed
EP-4578868-A1 CYCLIC PEPTIDE OR SALT THEREOF, AND MDMX INHIBITOR FUJIFILM Corporation (JP) 2025-07-02 — — EP disclosed
EP-4578867-A1 CYCLIC PEPTIDE OR SALT THEREOF AND MDMX INHIBITOR FUJIFILM Corporation (JP) 2025-07-02 — — EP disclosed
CN-120202010-A Ligand-oligonucleotide conjugates and linkers for use therewith 上海京新生物医药有限公司 2025-06-24 — — CN disclosed
US-20250179119-A1 CYCLIC PEPTIDE OR SALT THEREOF, AND MDMX INHIBITOR FUJIFILM CORPORATION (JP) 2025-06-05 — — US disclosed
US-20250179120-A1 CYCLIC PEPTIDE OR SALT THEREOF, AND MDMX INHIBITOR FUJIFILM CORPORATION (JP) 2025-06-05 — — US disclosed
US-20250084410-A1 INCORPORATION OF UNNATURAL NUCLEOTIDES AND METHODS THEREOF Synthorx, Inc. (US) 2025-03-13 — — US disclosed
EP-4041249-A1 COMPOSITIONS AND METHODS FOR IN VIVO SYNTHESIS OF UNNATURAL POLYPEPTIDES The Scripps Research Institute (US) 2022-08-17 — — EP disclosed
EP-4041247-A1 EUKARYOTIC SEMI-SYNTHETIC ORGANISMS The Scripps Research Institute (US) 2022-08-17 — — EP disclosed
WO-2022170108-A1 PEPTIDOMIMETIC MACROCYCLES AND USES THEREOF IN PREVENTION OF RADIATION INJURY AILERON THERAPEUTICS, INC. (US) 2022-08-11 — — WO disclosed
US-20220243244-A1 COMPOSITIONS AND METHODS FOR IN VIVO SYNTHESIS OF UNNATURAL POLYPEPTIDES NATIONAL INSTITUTES OF HEALTH 2022-08-04 — — US disclosed
US-20220226434-A1 METHODS OF TREATING HYPERLIPIDEMIA CONDITIONS WITH NETRIN-1 COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2022-07-21 — — US disclosed
US-20220228148-A1 EUKARYOTIC SEMI-SYNTHETIC ORGANISMS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2022-07-21 — — US disclosed
US-20220133893-A1 Therapeutic Nanomaterials UNIVERSITY OF CONNECTICUT 2022-05-05 — — US disclosed
WO-2022081721-A1 NANOMATERIAL AND METHODS OF USE THEREOF UNIVERSITY OF CONNECTICUT (US) 2022-04-21 — — WO disclosed
EP-3983543-A1 REAGENTS AND METHODS FOR REPLICATION, TRANSCRIPTION, AND TRANSLATION IN SEMI-SYNTHETIC ORGANISMS The Scripps Research Institute (US) 2022-04-20 — — EP disclosed
EP-3976635-A1 METHODS OF TREATING HYPERLIPIDEMIA CONDITIONS WITH NETRIN-1 COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-04-06 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250302971-A1 Therapeutic Nanomaterials TIE1, TEKT1, POLRMT METAP1 2379/4885SLC1A2 2109/4885SLC1A1 1389/4885
US-20250179119-A1 CYCLIC PEPTIDE OR SALT THEREOF, AND MDMX INHIBITOR MLX, BMX, ADM2 METAP1 41/4885SLC1A2 336/4885SLC1A1 302/4885
US-20220133893-A1 Therapeutic Nanomaterials TIE1, TEKT1, POLRMT METAP1 2379/4885SLC1A2 2109/4885SLC1A1 1389/4885
US-20250367300-A1 Nanomaterial and Methods of Use Thereof EPCAM, CD47, JAK2 METAP1 2030/4885SLC1A2 1557/4885SLC1A1 680/4885
US-20250302762-A1 NANOMATERIAL DELIVERY VEHICLE AND METHOD OF USE THEREOF JAK2, JAK1, CHMP4B METAP1 3140/4885SLC1A2 708/4885SLC1A1 431/4885
US-20250179120-A1 CYCLIC PEPTIDE OR SALT THEREOF, AND MDMX INHIBITOR MDN1, MLX, BMX METAP1 17/4885SLC1A2 1665/4885SLC1A1 1666/4885
US-20250084410-A1 INCORPORATION OF UNNATURAL NUCLEOTIDES AND METHODS THEREOF RNGTT, TRMT1, OSGEP METAP1 438/4885SLC1A2 737/4885SLC1A1 644/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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