Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
| ▸ | MPO | P05164 | 3/20 | 0.34 |
| ▸ | IDO1 | P14902 | 3/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | HTR2C | P28335 | 3/20 | 0.33 |
| ▸ | HTR2B | P41595 | 3/20 | 0.33 |
| ▸ | RBP4 | P02753 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2369695 | 1.00 | KEAP1 (0.36) | KEAP1FFAR1GRIN1GRIN2BPIN1 | |
| SCHEMBL2369799 | 0.81 | ALDH1A1 (0.42) | — | |
| SCHEMBL12289804 | 0.78 | ALDH1A1 (0.38) | KEAP1FFAR1GRIN1GRIN2BPIN1 | |
| SCHEMBL12256854 | 0.78 | ALDH1A1 (0.38) | KEAP1FFAR1GRIN1GRIN2BPIN1 | |
| SCHEMBL12256799 | 0.77 | ALDH1A1 (0.37) | KEAP1GRIN1GRIN2BIDO1SLC6A4 | |
| SCHEMBL2393556 | 0.77 | ALDH1A1 (0.37) | KEAP1GRIN1GRIN2BIDO1SLC6A4 | |
| SCHEMBL2393553 | 0.77 | ALDH1A1 (0.37) | KEAP1GRIN1GRIN2BIDO1SLC6A4 | |
| SCHEMBL12256793 | 0.77 | ALDH1A1 (0.37) | KEAP1GRIN1GRIN2BIDO1SLC6A4 | |
| SCHEMBL2393619 | 0.75 | IDO1 (0.43) | KEAP1IDO1 | |
| SCHEMBL2393623 | 0.75 | IDO1 (0.43) | KEAP1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2539345-A1 | 4 - [CYCLOALKYLOXY (HETERO) ARYLAMINO]THIENO [2, 3 - D]PYRIMIDINES HAVING MNKL/ MNK2 INHIBITING ACTIVITY FOR PHARMACEUTICAL COMPOSITIONS | Boehringer Ingelheim International GmbH (DE) | 2013-01-02 | — | — | EP | disclosed |
| WO-2011104334-A1 | 4 - [CYCLOALKYLOXY (HETERO) ARYLAMINO] THIENO [2, 3 - D] PYRIMIDINES HAVING MNKL/ MNK2 INHIBITING ACTIVITY FOR PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-09-01 | — | — | WO | disclosed |