Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 8/20 | 0.64 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | ALB | P02768 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23698064 | 0.93 | MGLL (0.62) | MGLLRAB9ATTRALBMAOA | |
| SCHEMBL23698057 | 0.85 | MGLL (0.61) | MGLLRAB9ATTRALBMAOA | |
| SCHEMBL23717019 | 0.84 | MGLL (0.60) | MGLLRAB9APKMNPC1SMN1; SMN2 | |
| SCHEMBL23698063 | 0.82 | MGLL (0.63) | MGLLRAB9ATTRALBMAOA | |
| SCHEMBL23698061 | 0.81 | MGLL (0.59) | MGLLRAB9ATTRALBMAOA | |
| SCHEMBL20898120 | 0.79 | MGLL (1.00) | MGLL | |
| SCHEMBL29784238 | 0.78 | MGLL (0.54) | MGLLSMN1; SMN2LMNATSHRKMT2A | |
| SCHEMBL23698058 | 0.78 | MGLL (0.56) | MGLLTTRALBMAOACNR1 | |
| SCHEMBL22442396 | 0.77 | MGLL (0.57) | MGLLRAB9ATTRALBMAOA | |
| SCHEMBL19128730 | 0.76 | MGLL (0.58) | MGLLTTRALBMAOACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3694840-B1 | PIPERAZINE DERIVATIVES AS MAGL INHIBITORS | HOFFMANN LA ROCHE (CH) | 2021-08-04 | — | — | EP | disclosed |