Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 8/20 | 0.60 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | ACACA | Q13085 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23698064 | 0.91 | MGLL (0.62) | MGLLLMNATSHRACACARAB9A | |
| SCHEMBL23698043 | 0.84 | MGLL (0.64) | MGLLLMNATSHRACACARAB9A | |
| SCHEMBL19214099 | 0.82 | MGLL (0.54) | MGLLLMNATSHRRAB9AMAPT | |
| SCHEMBL31349426 | 0.81 | MGLL (0.49) | MGLLRAB9AHPGDKMT2AMAPT | |
| SCHEMBL20296328 | 0.81 | RAB9A (0.52) | MGLLLMNATSHRRAB9APTGES | |
| SCHEMBL31349381 | 0.78 | RAB9A (0.51) | MGLLLMNAACACARAB9AKMT2A | |
| SCHEMBL20910382 | 0.76 | MGLL (0.60) | MGLLLMNATSHRRAB9AHPGD | |
| SCHEMBL20898127 | 0.76 | MGLL (1.00) | MGLL | |
| SCHEMBL23698061 | 0.76 | MGLL (0.59) | MGLLLMNATSHRRAB9APTGES | |
| SCHEMBL23717085 | 0.74 | MGLL (0.56) | MGLLLMNATSHRSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3694840-B1 | PIPERAZINE DERIVATIVES AS MAGL INHIBITORS | HOFFMANN LA ROCHE (CH) | 2021-08-04 | — | — | EP | disclosed |