Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.49 |
| ▸ | PHGDH | O43175 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23698305 | 1.00 | KMT2A (0.57) | KMT2ANPC1RAB9AMEN1HTT | |
| SCHEMBL30714864 | 0.85 | MAPT (0.61) | KMT2ANPC1RAB9AMEN1HTT | |
| SCHEMBL23698298 | 0.81 | ALDH1A1 (0.60) | KMT2ANPC1RAB9AMEN1HTT | |
| SCHEMBL23698299 | 0.81 | ALDH1A1 (0.60) | KMT2ANPC1RAB9AMEN1HTT | |
| SCHEMBL8291982 | 0.81 | MAPT (0.66) | KMT2ANPC1RAB9AMEN1HTT | |
| SCHEMBL21887603 | 0.78 | MAPT (0.68) | KMT2ANPC1RAB9AMEN1HTT | |
| SCHEMBL13628792 | 0.75 | ALDH1A1 (0.58) | KMT2ANPC1MEN1HTTMAPT | |
| SCHEMBL13673499 | 0.75 | HTT (0.56) | KMT2AMEN1HTTMAPTLMNA | |
| SCHEMBL13673500 | 0.75 | HTT (0.56) | KMT2AMEN1HTTMAPTLMNA | |
| SCHEMBL13673635 | 0.74 | HTT (0.49) | KMT2ANPC1RAB9AMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3858342-A1 | ACYLHYDRAZONES FOR THE TREATMENT OF NEUROLOGICAL DISEASES | Consejo Superior de Investigaciones Científicas (CSIC) (ES) | 2021-08-04 | — | — | EP | claimed |
| EP-3858342-A1 | ACYLHYDRAZONES FOR THE TREATMENT OF NEUROLOGICAL DISEASES | Consejo Superior de Investigaciones Científicas (CSIC) (ES) | 2021-08-04 | — | — | EP | disclosed |