Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.76 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.76 |
| ▸ | APAF1 | O14727 | 1/20 | 0.76 |
| ▸ | NPC1 | O15118 | 1/20 | 0.76 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.76 |
| ▸ | MAPT | P10636 | 1/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.76 |
| ▸ | HTT | P42858 | 1/20 | 0.76 |
| ▸ | RAB9A | P51151 | 1/20 | 0.76 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.76 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.76 |
| ▸ | FDPS | P14324 | 17/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL23698459 | 1.00 | MEN1 (0.76) | MEN1HSP90AA1KMT2ASMN1; SMN2APAF1 | |
| Bicarbonate SCHEMBL23698438 | 0.94 | MEN1 (0.76) | MEN1HSP90AA1KMT2ASMN1; SMN2APAF1 | |
| Bicarbonate SCHEMBL6265471 | 0.94 | MEN1 (0.76) | MEN1HSP90AA1KMT2ASMN1; SMN2APAF1 | |
| Acetic Acid SCHEMBL3140604 | 0.94 | MEN1 (0.76) | MEN1HSP90AA1KMT2ASMN1; SMN2APAF1 | |
| Bicarbonate SCHEMBL23698460 | 0.94 | MEN1 (0.76) | MEN1HSP90AA1KMT2ASMN1; SMN2APAF1 | |
| Acetic Acid SCHEMBL23090491 | 0.94 | MEN1 (0.76) | MEN1HSP90AA1KMT2ASMN1; SMN2APAF1 | |
| Bicarbonate SCHEMBL23698463 | 0.94 | MEN1 (0.76) | MEN1HSP90AA1KMT2ASMN1; SMN2APAF1 | |
| Acetic Acid SCHEMBL23004172 | 0.94 | MEN1 (0.76) | MEN1HSP90AA1KMT2ASMN1; SMN2APAF1 | |
| Acetic Acid SCHEMBL2787360 | 0.94 | MEN1 (0.76) | MEN1HSP90AA1KMT2ASMN1; SMN2APAF1 | |
| Acetic Acid SCHEMBL1660890 | 0.94 | MEN1 (0.76) | MEN1HSP90AA1KMT2ASMN1; SMN2APAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12291506-B2 | Method for producing amidate compound, and amidate compound | KOEI CHEMICAL COMPANY, LIMITED (JP) | 2025-05-06 | — | — | US | disclosed |
| US-20220048864-A1 | METHOD FOR PRODUCING AMIDATE COMPOUND, AND AMIDATE COMPOUND | KOEI CHEMICAL COMPANY, LIMITED (JP) | 2022-02-17 | — | — | US | disclosed |
| EP-3858817-A1 | METHOD FOR PRODUCING AMIDATE COMPOUND, AND AMIDATE COMPOUND | Koei Chemical Company, Limited (JP) | 2021-08-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12291506-B2 | Method for producing amidate compound, and amidate compound | NAAA, NIT2, PAM | MEN1 55/4885HSP90AA1 4241/4885KMT2A 4207/4885 |
| US-20220048864-A1 | METHOD FOR PRODUCING AMIDATE COMPOUND, AND AMIDATE COMPOUND | NAAA, NIT2, PAM | MEN1 55/4885HSP90AA1 4241/4885KMT2A 4207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.