Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | FDPS | P14324 | 19/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL23698489 | 1.00 | MEN1 (0.63) | MEN1HSP90AA1KMT2ASMN1; SMN2FDPS | |
| Bicarbonate SCHEMBL23698391 | 1.00 | MEN1 (0.63) | MEN1HSP90AA1KMT2ASMN1; SMN2FDPS | |
| Bicarbonate SCHEMBL23698472 | 1.00 | MEN1 (0.63) | MEN1HSP90AA1KMT2ASMN1; SMN2FDPS | |
| Bicarbonate SCHEMBL23698534 | 1.00 | MEN1 (0.63) | MEN1HSP90AA1KMT2ASMN1; SMN2FDPS | |
| Bicarbonate SCHEMBL23698395 | 1.00 | MEN1 (0.63) | MEN1HSP90AA1KMT2ASMN1; SMN2FDPS | |
| Bicarbonate SCHEMBL23698494 | 1.00 | MEN1 (0.63) | MEN1HSP90AA1KMT2ASMN1; SMN2FDPS | |
| Bicarbonate SCHEMBL23698567 | 1.00 | MEN1 (0.63) | MEN1HSP90AA1KMT2ASMN1; SMN2FDPS | |
| Bicarbonate SCHEMBL23698565 | 1.00 | MEN1 (0.63) | MEN1HSP90AA1KMT2ASMN1; SMN2FDPS | |
| Bicarbonate SCHEMBL28553511 | 0.97 | MEN1 (0.59) | MEN1HSP90AA1KMT2ASMN1; SMN2FDPS | |
| Bicarbonate SCHEMBL23698538 | 0.97 | MEN1 (0.63) | MEN1HSP90AA1KMT2ASMN1; SMN2FDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12291506-B2 | Method for producing amidate compound, and amidate compound | KOEI CHEMICAL COMPANY, LIMITED (JP) | 2025-05-06 | — | — | US | disclosed |
| CN-118290346-A | Method for producing amide compound, and amide compound | 广荣化学株式会社 | 2024-07-05 | — | — | CN | disclosed |
| CN-112703184-B | Method for producing amide compound, and amide compound | 广荣化学株式会社 | 2024-06-11 | — | — | CN | disclosed |
| US-20220048864-A1 | METHOD FOR PRODUCING AMIDATE COMPOUND, AND AMIDATE COMPOUND | KOEI CHEMICAL COMPANY, LIMITED (JP) | 2022-02-17 | — | — | US | disclosed |
| EP-3858817-A1 | METHOD FOR PRODUCING AMIDATE COMPOUND, AND AMIDATE COMPOUND | Koei Chemical Company, Limited (JP) | 2021-08-04 | — | — | EP | disclosed |
| CN-112703184-A | Process for producing amide compound, and amide compound | 广荣化学株式会社 | 2021-04-23 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12291506-B2 | Method for producing amidate compound, and amidate compound | NAAA, NIT2, PAM | MEN1 55/4885HSP90AA1 4241/4885KMT2A 4207/4885 |
| US-20220048864-A1 | METHOD FOR PRODUCING AMIDATE COMPOUND, AND AMIDATE COMPOUND | NAAA, NIT2, PAM | MEN1 55/4885HSP90AA1 4241/4885KMT2A 4207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.