SCHEMBL23699256

SCHEMBL23699256

Cc1cc(-c2ncc(CNC(=O)c3cc(-c4ccc(F)cn4)on3)cc2C)ccn1

nearest known ligand 0.53

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ WNT3A P56704 9/20 0.53
▸ POLB P06746 1/20 0.44
▸ SMN1; SMN2 Q16637 1/20 0.44
▸ TP53 P04637 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20507940 0.88 WNT3A (0.57) WNT3APOLBSMN1; SMN2TP53
SCHEMBL20507964 0.86 WNT3A (0.47) WNT3APOLBSMN1; SMN2TP53
SCHEMBL20508213 0.86 WNT3A (0.56) WNT3APOLBSMN1; SMN2TP53
SCHEMBL20507899 0.85 WNT3A (0.48) WNT3APOLBSMN1; SMN2TP53
SCHEMBL18974100 0.84 RAB9A (0.58) WNT3APOLBSMN1; SMN2TP53
SCHEMBL20508020 0.84 WNT3A (0.49) WNT3APOLBSMN1; SMN2TP53
SCHEMBL20508039 0.84 SCD (0.47) WNT3APOLBSMN1; SMN2TP53
SCHEMBL28515409 0.79 WNT3A (0.53) WNT3A
SCHEMBL248933 0.78 WNT3A (0.51) WNT3A
SCHEMBL20508028 0.76 WNT3A (0.56) WNT3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3388428-B1 FIVE-MEMBERED HETEROCYCLIC AMIDES WNT PATHWAY INHIBITOR SUZHOU SINOVENT PHARMACEUTICALS COMPANY (CN) 2021-08-04 — — EP claimed
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