Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 7/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 2/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.34 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.34 |
| ▸ | STK17B | O94768 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27909504 | 0.76 | STK17B (0.36) | TYK2KITRAB9ANPC1KMT2A | |
| SCHEMBL27909495 | 0.76 | STK17B (0.51) | TYK2RAB9ANPC1KMT2ASTK17B | |
| SCHEMBL27909505 | 0.76 | IKBKB (0.32) | IKBKBSTK17B | |
| SCHEMBL27909499 | 0.76 | STK17B (0.36) | TYK2KITMAP3K8RAB9ANPC1 | |
| SCHEMBL27909497 | 0.76 | HRH3 (0.44) | STK17B | |
| SCHEMBL27892406 | 0.74 | CYP2D6 (0.47) | CYP2C19 | |
| SCHEMBL27892397 | 0.74 | IKBKB (0.31) | IKBKBSTK17B | |
| SCHEMBL28066464 | 0.74 | EGFR (0.43) | — | |
| SCHEMBL27909526 | 0.73 | HRH3 (0.47) | CYP1A2CYP3A4TDP1 | |
| SCHEMBL27909503 | 0.73 | MAP4K4 (0.39) | TYK2KITRAB9ANPC1MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2892534-B1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC (US) | 2021-08-04 | — | — | EP | disclosed |