Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.36 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19808820 | 0.89 | MAPK1 (0.39) | HRH3ALDH1A1L3MBTL1MAPK1SMN1; SMN2 | |
| SCHEMBL4250116 | 0.73 | MAPT (0.54) | MAPTHRH3ALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL19808815 | 0.73 | HRH3 (0.47) | HRH3L3MBTL1MAPK1SMN1; SMN2 | |
| SCHEMBL13875913 | 0.71 | NPC1 (0.43) | HRH3ALDH1A1HPGDMAPK1SMN1; SMN2 | |
| SCHEMBL19808881 | 0.71 | GABRA5 (0.42) | XDHHRH3ALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL19808807 | 0.71 | LMNA (0.41) | MAPTHRH3L3MBTL1MAPK1 | |
| SCHEMBL4255464 | 0.71 | MAPT (0.54) | MAPTL3MBTL1SMN1; SMN2LPAR1LPAR5 | |
| SCHEMBL3112611 | 0.70 | NOTUM (0.40) | XDHMAPTALDH1A1HPGDL3MBTL1 | |
| SCHEMBL18609606 | 0.70 | HTT (0.51) | MAPTALDH1A1L3MBTL1 | |
| SCHEMBL19808874 | 0.70 | MAPT (0.47) | MAPTHRH3L3MBTL1HCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3275881-B1 | COMPOUND OF 5-HYDROXYL-1,7-NAPHTHYRIDINE SUBSTITUTED BY ARYLOXY OR HETEROOXY, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE THEREOF | SHENYANG SUNSHINE PHARMACEUTICAL CO LTD (CN) | 2021-08-04 | — | — | EP | disclosed |