Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 4/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19808823 | 0.89 | JAK2 (0.48) | JAK2JAK1JAK3HRH3EGLN1 | |
| SCHEMBL28246634 | 0.83 | F10 (0.41) | JAK2JAK1JAK3HRH3F10 | |
| SCHEMBL6576129 | 0.81 | F10 (0.65) | JAK2JAK1JAK3HRH3EGLN1 | |
| SCHEMBL19808866 | 0.80 | EGLN1 (0.48) | JAK2JAK1JAK3HRH3EGLN1 | |
| SCHEMBL19808803 | 0.75 | JAK2 (0.44) | JAK2JAK1JAK3EGLN1MAP4K4 | |
| SCHEMBL19808875 | 0.75 | P2RX3 (0.41) | HRH3EGLN1PTGER4XDHSLC22A12 | |
| SCHEMBL6579300 | 0.75 | MAP4K4 (0.62) | JAK2JAK1JAK3HRH3EGLN1 | |
| SCHEMBL6578795 | 0.74 | F10 (0.62) | JAK2JAK1JAK3HRH3EGLN1 | |
| SCHEMBL6773056 | 0.73 | F10 (0.67) | JAK2JAK1JAK3EGLN1F10 | |
| SCHEMBL19808883 | 0.73 | L3MBTL1 (0.52) | JAK2JAK1JAK3HRH3EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3275881-B1 | COMPOUND OF 5-HYDROXYL-1,7-NAPHTHYRIDINE SUBSTITUTED BY ARYLOXY OR HETEROOXY, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE THEREOF | SHENYANG SUNSHINE PHARMACEUTICAL CO LTD (CN) | 2021-08-04 | — | — | EP | disclosed |