Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.52 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | PNMT | P11086 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 4/20 | 0.46 |
| ▸ | MAOB | P27338 | 4/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30014406 | 1.00 | HRH3 (0.52) | HRH3CREBBPADRA2APNMTADRA2B | |
| SCHEMBL31627898 | 0.81 | HDAC8 (0.57) | HRH3MAOAMAOB | |
| SCHEMBL28923896 | 0.80 | CREBBP (0.67) | HRH3CREBBPCYP2D6KDM1AMAOA | |
| SCHEMBL31444075 | 0.80 | CREBBP (0.67) | HRH3CREBBPCYP2D6KDM1AMAOA | |
| SCHEMBL3054428 | 0.79 | CHRNA7 (0.51) | — | |
| SCHEMBL4043474 | 0.77 | MCHR1 (0.58) | — | |
| SCHEMBL12471199 | 0.75 | HRH3 (0.51) | HRH3CYP2D6KDM1AHRH1MAOA | |
| SCHEMBL5680586 | 0.74 | MAPKAPK2 (0.54) | CREBBPMAOAMAOB | |
| SCHEMBL12471689 | 0.73 | HRH3 (0.52) | HRH3CYP2D6KDM1AHRH1MAOA | |
| SCHEMBL29474892 | 0.73 | HRH3 (0.59) | HRH3PNMTCYP2D6KDM1AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4077306-B1 | COMPOUNDS AND PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION INC (US) | 2025-05-07 | — | — | EP | disclosed |
| US-11992535-B2 | Compounds and probes for imaging huntingtin protein | CHDI FOUNDATION, INC. (US) | 2024-05-28 | — | — | US | disclosed |
| US-20210236663-A1 | COMPOUNDS AND PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. | 2021-08-05 | — | — | US | disclosed |
| US-20210236663-A1 | COMPOUNDS AND PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. | 2021-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210236663-A1 | COMPOUNDS AND PROBES FOR IMAGING HUNTINGTIN PROTEIN | HTT, HYPK, HSPBP1 | HRH3 3299/4885CREBBP 300/4885ADRA2A 4512/4885 |
| US-11992535-B2 | Compounds and probes for imaging huntingtin protein | HTT, HYPK, HSPBP1 | HRH3 3299/4885CREBBP 300/4885ADRA2A 4512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.