Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.53 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 2/20 | 0.44 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31553210 | 0.90 | NPC1 (0.50) | MAPTNR1H2TMPRSS2ESR2NPC1 | |
| SCHEMBL23701095 | 0.81 | NPC1 (0.56) | MAPTTMPRSS2NPC1KMT2ATSHR | |
| SCHEMBL30014687 | 0.81 | NPC1 (0.56) | MAPTTMPRSS2NPC1KMT2ATSHR | |
| SCHEMBL6438594 | 0.80 | NR1H2 (0.70) | MAPTNR1H2ESR2NPC1TSHR | |
| SCHEMBL30390692 | 0.80 | NR1H2 (0.70) | MAPTNR1H2ESR2NPC1TSHR | |
| SCHEMBL1188497 | 0.80 | ESR2 (0.60) | MAPTNR1H2TMPRSS2ESR2NPC1 | |
| SCHEMBL31174273 | 0.79 | NR1H2 (0.66) | MAPTNR1H2ESR2NPC1KMT2A | |
| SCHEMBL23253800 | 0.79 | NR1H2 (0.52) | MAPTNR1H2ESR2NPC1KMT2A | |
| SCHEMBL23538217 | 0.79 | NR1H2 (0.54) | MAPTNR1H2ESR2KMT2AMEN1 | |
| SCHEMBL30014445 | 0.79 | NR1H2 (0.54) | MAPTNR1H2ESR2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4077306-B1 | COMPOUNDS AND PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION INC (US) | 2025-05-07 | — | — | EP | disclosed |
| US-11992535-B2 | Compounds and probes for imaging huntingtin protein | CHDI FOUNDATION, INC. (US) | 2024-05-28 | — | — | US | disclosed |
| US-20210236663-A1 | COMPOUNDS AND PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. | 2021-08-05 | — | — | US | disclosed |
| US-20210236663-A1 | COMPOUNDS AND PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. | 2021-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210236663-A1 | COMPOUNDS AND PROBES FOR IMAGING HUNTINGTIN PROTEIN | HTT, HYPK, HSPBP1 | MAPT 4/4885NR1H2 3900/4885TMPRSS2 4240/4885 |
| US-11992535-B2 | Compounds and probes for imaging huntingtin protein | HTT, HYPK, HSPBP1 | MAPT 4/4885NR1H2 3900/4885TMPRSS2 4240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.