Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 11/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23701381 | 0.93 | MAPT (0.43) | MAPTGFERSMN1; SMN2POLBACACB | |
| SCHEMBL23701382 | 0.93 | MAPT (0.43) | MAPTGFERSMN1; SMN2POLBACACB | |
| SCHEMBL23701453 | 0.88 | ACACB (0.47) | MAPTGFERSMN1; SMN2POLBACACB | |
| SCHEMBL23701451 | 0.88 | ACACB (0.47) | MAPTGFERSMN1; SMN2POLBACACB | |
| SCHEMBL23701363 | 0.83 | ACACB (0.53) | ACACBALDH1A1KMT2A | |
| SCHEMBL23701362 | 0.83 | ACACB (0.53) | ACACBALDH1A1KMT2A | |
| SCHEMBL23701469 | 0.80 | KMT2A (0.43) | MAPTACACBALDH1A1TP53KMT2A | |
| SCHEMBL27400138 | 0.78 | KMT2A (0.46) | ACACBKMT2A | |
| SCHEMBL23701430 | 0.77 | ACACB (0.46) | ACACBKMT2A | |
| SCHEMBL23701429 | 0.77 | ACACB (0.46) | ACACBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210238179-A1 | HEXAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES USEFUL AS LOX INHIBITORS | THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) | 2021-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210238179-A1 | HEXAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES USEFUL AS LOX INHIBITORS | LOX, LOXL1, LOXL3 | MAPT 4829/4885GFER 783/4885SMN1; SMN2 3383/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.