SCHEMBL23701602

SCHEMBL23701602

O=C(NNC(=O)C1CCN(C(=O)O)C1)c1ccccc1Nc1ccc(C(F)(F)F)cc1

nearest known ligand 0.53

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ RXFP1 Q9HBX9 7/20 0.53
▸ TRPV1 Q8NER1 2/20 0.46
▸ SMO Q99835 3/20 0.44
▸ MTTP P55157 1/20 0.43
▸ MAPK8 P45983 1/20 0.42
▸ GAA P10253 1/20 0.42
▸ TDP1 Q9NUW8 1/20 0.42
▸ KDM4C Q9H3R0 1/20 0.41
▸ RHOC P08134 1/20 0.41
▸ RHOA P61586 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22556320 1.00 RXFP1 (0.53) RXFP1TRPV1SMOMTTPMAPK8
SCHEMBL30463796 0.87 KMT2A (0.51) RXFP1
SCHEMBL23701612 0.80 RXFP1 (0.50) RXFP1TRPV1SMOMAPK8RHOC
SCHEMBL22556334 0.77 RXFP1 (0.53) RXFP1MAPK8GAATDP1
SCHEMBL29888333 0.75 RXFP1 (0.48) RXFP1SMO
SCHEMBL22571443 0.75 GAA (0.57) RXFP1GAATDP1
SCHEMBL22556321 0.73 RXFP1 (0.53) RXFP1MAPK8
SCHEMBL4245559 0.73 MAPK8 (0.67) RXFP1MAPK8
SCHEMBL23713156 0.73 RXFP1 (0.47) RXFP1MAPK8
SCHEMBL22556306 0.73 RXFP1 (0.53) RXFP1MAPK8GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11661403-B2 Oxadiazole compounds VIVACE THERAPEUTICS, INC. (US) 2023-05-30 — — US disclosed
US-20210238154-A1 OXADIAZOLE COMPOUNDS VIVACE THERAPEUTICS, INC. 2021-08-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210238154-A1 OXADIAZOLE COMPOUNDS YAP1, TEAD2, TEAD3 RXFP1 3511/4885TRPV1 4341/4885SMO 313/4885
US-11661403-B2 Oxadiazole compounds YAP1, TEAD2, TEAD3 RXFP1 3511/4885TRPV1 4341/4885SMO 313/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback