Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ACP1 | P24666 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2370042 | 0.84 | AURKB (0.46) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL143634 | 0.84 | MAPT (0.49) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2369866 | 0.82 | AURKB (0.46) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2370374 | 0.81 | KMT2A (0.56) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2370220 | 0.79 | ALDH1A1 (0.59) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4908275 | 0.77 | ALDH1A1 (0.71) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5001543 | 0.76 | RIPK1 (0.63) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL140510 | 0.75 | ITK (0.76) | MAPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL140511 | 0.75 | ITK (0.76) | MAPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL5001727 | 0.74 | RIPK1 (0.67) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011110575-A1 | DERIVATIVES OF 2-[2-(BENZO- OR PYRIDO-) THIAZOLYLAMINO]-6-AMINOPYRIDINE, USEFUL IN THE TREATMENT OF RESPIRATORIC, ALLERGIC OR INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2011-09-15 | — | — | WO | disclosed |