Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LNPEP | Q9UIQ6 | 9/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 2/20 | 0.32 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23731421 | 0.83 | SREBF2 (0.36) | LNPEPKDM4EARMAPT | |
| SCHEMBL19783105 | 0.80 | KDM4E (0.43) | LNPEPKDM4EALDH1A1SMN1; SMN2AR | |
| Hydrazine SCHEMBL28514079 | 0.77 | KDM4E (0.41) | LNPEPKDM4EALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL29186948 | 0.75 | S1PR1 (0.36) | KDM4ENUDT1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL12434098 | 0.73 | KDM4E (0.37) | KDM4EALDH1A1SMN1; SMN2CYP1A2POLB | |
| SCHEMBL20573162 | 0.72 | KDM4E (0.38) | LNPEPKDM4EALDH1A1SMN1; SMN2NUDT1 | |
| SCHEMBL31451327 | 0.71 | NOS3 (0.33) | KDM4EALDH1A1SMN1; SMN2CYP1A2NOS3 | |
| SCHEMBL31416644 | 0.70 | — | — | |
| SCHEMBL539467 | 0.70 | — | — | |
| SCHEMBL22637134 | 0.70 | DYRK1A (0.38) | KDM4EALDH1A1SMN1; SMN2NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4096659-A1 | SREBP INHIBITORS COMPRISING A THIOPHENE CENTRAL RING | Capulus Therapeutics, LLC (US) | 2022-12-07 | — | — | EP | disclosed |
| WO-2021154735-A1 | SREBP INHIBITORS COMPRISING A THIOPHENE CENTRAL RING | CAPULUS THERAPEUTICS, LLC (US) | 2021-08-05 | — | — | WO | disclosed |
| WO-2021154735-A1 | SREBP INHIBITORS COMPRISING A THIOPHENE CENTRAL RING | CAPULUS THERAPEUTICS, LLC (US) | 2021-08-05 | — | — | WO | disclosed |