Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 5/20 | 0.36 |
| ▸ | HTR6 | P50406 | 5/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | HTR3A | P46098 | 2/20 | 0.32 |
| ▸ | USP1 | O94782 | 2/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | PRKCB | P05771 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL820570 | 0.75 | DYRK1A (0.47) | DYRK1AGSK3BPRMT5WDR77TLR9 | |
| SCHEMBL18993230 | 0.71 | DYRK1A (0.49) | HTR6DYRK1APRKCBGSK3BTLR9 | |
| SCHEMBL20697023 | 0.67 | CNR2 (0.53) | PRKCBGSK3B | |
| SCHEMBL20697252 | 0.66 | GSK3B (0.53) | PRKCBGSK3B | |
| SCHEMBL24117380 | 0.65 | PDPK1 (0.36) | DYRK1AGSK3BTLR9TLR8TLR7 | |
| SCHEMBL15077818 | 0.65 | DYRK1A (0.44) | DYRK1AGSK3BPRMT5WDR77TLR9 | |
| SCHEMBL12874831 | 0.64 | PDE4A (0.41) | DYRK1AGSK3B | |
| SCHEMBL21227429 | 0.63 | HTR6 (0.49) | HTR6 | |
| SCHEMBL21245970 | 0.63 | HTR6 (0.42) | HTR6GSK3B | |
| SCHEMBL23937871 | 0.63 | DYRK1A (0.46) | HTR6DYRK1APRKCBGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11078201-B2 | Substituted isoindolin-1-ones and 2,3-dihydro-1H-pyrrol[3,4-c]pyridin-1-ones as HPK1 antagonists | Nimbus Saturn, Inc. (US) | 2021-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11078201-B2 | Substituted isoindolin-1-ones and 2,3-dihydro-1H-pyrrol[3,4-c]pyridin-1-ones as HPK1 antagonists | HIPK1, PDXK, IP6K1 | MAT2A 2154/4885HTR6 423/4885DYRK1A 488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.