Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 10/20 | 0.45 |
| ▸ | FNTB | P49356 | 10/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.38 |
| ▸ | PGGT1B | P53609 | 4/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | NRAS | P01111 | 1/20 | 0.34 |
| ▸ | HRAS | P01112 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | CPA1 | P15085 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7749673 | 0.93 | FNTA (0.53) | FNTAFNTBCYP19A1PGGT1BHRH3 | |
| SCHEMBL7515948 | 0.86 | FNTA (0.41) | FNTAFNTBCYP19A1PGGT1BHRH3 | |
| SCHEMBL3498159 | 0.85 | FNTA (0.38) | FNTAFNTBCYP19A1PGGT1BHRH3 | |
| SCHEMBL3500065 | 0.84 | FNTA (0.35) | FNTAFNTBCYP19A1PGGT1BHRH3 | |
| Hydrochloric Acid SCHEMBL7655739 | 0.84 | FNTA (0.37) | FNTAFNTBCYP19A1PGGT1BHRH3 | |
| Hydrochloric Acid SCHEMBL7662498 | 0.84 | ADRA1D (0.35) | FNTAFNTBCYP19A1PGGT1BHRH3 | |
| SCHEMBL3500207 | 0.82 | FNTA (0.43) | FNTAFNTBCYP19A1PGGT1BHRH3 | |
| SCHEMBL1683543 | 0.82 | FNTA (0.53) | FNTAFNTBPGGT1BNRASHRAS | |
| Water SCHEMBL7194386 | 0.82 | FNTA (0.53) | FNTAFNTBPGGT1BNRASHRAS | |
| SCHEMBL7972250 | 0.82 | FNTA (0.53) | FNTAFNTBPGGT1BNRASHRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2547661-A2 | INDAZOLE COMPOUNDS AND THEIR USES | Dana-Farber Cancer Institute, Inc. (US) | 2013-01-23 | — | — | EP | disclosed |
| WO-2011115725-A2 | INDAZOLE COMPOUNDS AND THEIR USES | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2011-09-22 | — | — | WO | disclosed |
| EP-1503757-A4 | TYROSINE KINASE INHIBITORS | MERCK & CO INC (US) | 2005-11-16 | — | — | EP | disclosed |
| EP-1503757-A2 | TYROSINE KINASE INHIBITORS | Merck & Co., Inc. (US) | 2005-02-09 | — | — | EP | disclosed |
| WO-2003092595-A2 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC (US) | 2003-11-13 | — | — | WO | disclosed |