Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 9/20 | 0.53 |
| ▸ | FNTB | P49356 | 9/20 | 0.53 |
| ▸ | PGGT1B | P53609 | 3/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NRAS | P01111 | 1/20 | 0.34 |
| ▸ | HRAS | P01112 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2370713 | 0.93 | FNTA (0.45) | FNTAFNTBPGGT1BCYP19A1NRAS | |
| SCHEMBL7515948 | 0.87 | FNTA (0.41) | FNTAFNTBPGGT1BCYP19A1NRAS | |
| SCHEMBL7453424 | 0.85 | FNTA (0.53) | FNTAFNTBPGGT1BCYP19A1ADRA2A | |
| SCHEMBL3498159 | 0.83 | FNTA (0.38) | FNTAFNTBPGGT1BCYP19A1NRAS | |
| SCHEMBL3500065 | 0.83 | FNTA (0.35) | FNTAFNTBPGGT1BCYP19A1ADRA1D | |
| Hydrochloric Acid SCHEMBL7655739 | 0.83 | FNTA (0.37) | FNTAFNTBPGGT1BCYP19A1NRAS | |
| Hydrochloric Acid SCHEMBL7662498 | 0.82 | ADRA1D (0.35) | FNTAFNTBPGGT1BCYP19A1ADRA1D | |
| SCHEMBL1683543 | 0.82 | FNTA (0.53) | FNTAFNTBPGGT1BNRASHRAS | |
| SCHEMBL7972250 | 0.82 | FNTA (0.53) | FNTAFNTBPGGT1BNRASHRAS | |
| Water SCHEMBL7194386 | 0.82 | FNTA (0.53) | FNTAFNTBPGGT1BNRASHRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906099-A4 | A METHOD OF TREATING CANCER | MERCK & CO INC (US) | 2001-02-07 | — | — | EP | claimed |
| EP-0952842-A2 | A METHOD OF TREATING CANCER | Merck & Co., Inc. (US) | 1999-11-03 | — | — | EP | claimed |
| EP-0906099-A1 | A METHOD OF TREATING CANCER | Merck & Co., Inc. (US) | 1999-04-07 | — | — | EP | claimed |
| WO-1997038664-A2 | A METHOD OF TREATING CANCER | MERCK & CO., INC. (US) | 1997-10-23 | — | — | WO | claimed |
| WO-1997036587-A1 | A METHOD OF TREATING CANCER | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | claimed |
| EP-0952842-A2 | A METHOD OF TREATING CANCER | Merck & Co., Inc. (US) | 1999-11-03 | — | — | EP | disclosed |
| WO-1997038664-A2 | A METHOD OF TREATING CANCER | MERCK & CO., INC. (US) | 1997-10-23 | — | — | WO | disclosed |