Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 4/20 | 0.41 |
| ▸ | BRD4 | O60885 | 5/20 | 0.35 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.35 |
| ▸ | BRD2 | P25440 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.31 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.31 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | ACE | P12821 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24456727 | 0.82 | SRD5A1 (0.44) | SRD5A1BRD4SRD5A2BRD2TACR1 | |
| SCHEMBL7875670 | 0.82 | SRD5A1 (0.44) | SRD5A1BRD4SRD5A2BRD2TACR1 | |
| SCHEMBL23107036 | 0.82 | SRD5A1 (0.44) | SRD5A1BRD4SRD5A2BRD2TACR1 | |
| SCHEMBL21408662 | 0.74 | HCAR2 (0.33) | ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL917756 | 0.74 | HCAR2 (0.33) | ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL21254092 | 0.73 | BRD4 (0.45) | SRD5A1BRD4SRD5A2BRD2 | |
| SCHEMBL23132331 | 0.72 | PIK3CD (0.38) | BRD4BRD2ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL26326345 | 0.72 | PIK3CD (0.38) | BRD4BRD2ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL21859839 | 0.71 | BRD4 (0.47) | SRD5A1BRD4SRD5A2BRD2CYP11B2 | |
| SCHEMBL23107033 | 0.71 | BRD4 (0.47) | SRD5A1BRD4SRD5A2BRD2CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11078201-B2 | Substituted isoindolin-1-ones and 2,3-dihydro-1H-pyrrol[3,4-c]pyridin-1-ones as HPK1 antagonists | Nimbus Saturn, Inc. (US) | 2021-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11078201-B2 | Substituted isoindolin-1-ones and 2,3-dihydro-1H-pyrrol[3,4-c]pyridin-1-ones as HPK1 antagonists | HIPK1, PDXK, IP6K1 | SRD5A1 2100/4885BRD4 1299/4885SRD5A2 2447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.